Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MSH4MutS-like protein 4. (1006 aa)    
Predicted Functional Partners:
ZFYVE9
MutS-like protein 5.
  
0.996
MLH1
DNA mismatch repair protein Mlh1.
 
 0.996
MLH3
DNA mismatch repair protein Mlh3.
  
 0.994
SPTLC1
Mismatch repair endonuclease PMS2.
 
 0.991
Msh2
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
  
0.979
Msh6
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
  
  
0.964
FANCM
Fanconi anemia group M protein.
    
 
 0.946
RAD51
DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily.
   
 0.927
TOP3A
DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.
   
 0.891
ATR
Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.
   
 
 0.886
Your Current Organism:
Trichinella sp. T6
NCBI taxonomy Id: 92179
Other names: T. sp. T6, Trichinella T6
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