STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AS27_04347DNA mismatch repair protein Msh6; Component of the post-replicative DNA mismatch repair system (MMR). (1152 aa)    
Predicted Functional Partners:
AS27_07767
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
  
0.999
AS27_01336
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
  
 0.998
AS27_09958
DNA mismatch repair protein Msh3.
  
 
0.993
AS27_10039
DNA mismatch repair protein Mlh1.
  
 0.990
AS27_12204
Mismatch repair endonuclease PMS2.
  
 0.984
AS27_00226
Exonuclease 1.
   
 0.972
AS27_02179
PMS1 protein 1.
 
 0.963
AS27_04472
DNA mismatch repair protein Mlh3.
  
 0.934
AS27_07566
DNA polymerase.
  
 
 0.932
AS27_04274
Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
   
 0.928
Your Current Organism:
Aptenodytes forsteri
NCBI taxonomy Id: 9233
Other names: A. forsteri, emperor penguin
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.