PTPRR protein (Pygoscelis adeliae) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

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Score

PTPRR

Receptor-type tyrosine-protein phosphatase R. (542 aa)

Predicted Functional Partners:

MAPK1

0.972

MAPK14

0.946

MAPK12

0.946

MAPK11

0.946

MAPK13

0.946

PTPN5

0.928

DUSP3

0.907

PTPN7

0.903

MAPK10

0.900

MAPK8

0.900

Your Current Organism:

Pygoscelis adeliae

NCBI taxonomy Id: 9238
Other names: Adelie penguin, P. adeliae, Pygoscelis adelia

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DUSP3	MAPK1	A0A093N8W4	A0A093PI48	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase.	0.947
DUSP3	MAPK10	A0A093N8W4	A0A093NB32	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase.	0.927
DUSP3	MAPK11	A0A093N8W4	A0A093PKP5	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase.	0.934
DUSP3	MAPK12	A0A093N8W4	A0A093P8J9	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase.	0.934
DUSP3	MAPK13	A0A093N8W4	A0A093QVR7	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase.	0.934
DUSP3	MAPK14	A0A093N8W4	A0A093NLE3	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase.	0.934
DUSP3	MAPK8	A0A093N8W4	A0A093QQJ4	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase.	0.927
DUSP3	PTPN5	A0A093N8W4	A0A093P7R7	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Tyrosine-protein phosphatase non-receptor type 5.	0.905
DUSP3	PTPN7	A0A093N8W4	A0A093NIC7	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Tyrosine-protein phosphatase non-receptor type 7.	0.922
DUSP3	PTPRR	A0A093N8W4	A0A093P5T5	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Receptor-type tyrosine-protein phosphatase R.	0.907
MAPK1	DUSP3	A0A093PI48	A0A093N8W4	Mitogen-activated protein kinase.	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.947
MAPK1	MAPK11	A0A093PI48	A0A093PKP5	Mitogen-activated protein kinase.	Mitogen-activated protein kinase.	0.946
MAPK1	MAPK12	A0A093PI48	A0A093P8J9	Mitogen-activated protein kinase.	Mitogen-activated protein kinase.	0.940
MAPK1	MAPK13	A0A093PI48	A0A093QVR7	Mitogen-activated protein kinase.	Mitogen-activated protein kinase.	0.940
MAPK1	MAPK14	A0A093PI48	A0A093NLE3	Mitogen-activated protein kinase.	Mitogen-activated protein kinase.	0.946
MAPK1	PTPN5	A0A093PI48	A0A093P7R7	Mitogen-activated protein kinase.	Tyrosine-protein phosphatase non-receptor type 5.	0.934
MAPK1	PTPN7	A0A093PI48	A0A093NIC7	Mitogen-activated protein kinase.	Tyrosine-protein phosphatase non-receptor type 7.	0.983
MAPK1	PTPRR	A0A093PI48	A0A093P5T5	Mitogen-activated protein kinase.	Receptor-type tyrosine-protein phosphatase R.	0.972
MAPK10	DUSP3	A0A093NB32	A0A093N8W4	Mitogen-activated protein kinase.	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.927
MAPK10	MAPK8	A0A093NB32	A0A093QQJ4	Mitogen-activated protein kinase.	Mitogen-activated protein kinase.	0.900

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.929

expected number of edges:

25

PPI enrichment p-value:

5.97e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019646

Aerobic electron transport chain

10 of 44

2.5

9.29

7.54e-21

GO:0042775

Mitochondrial ATP synthesis coupled electron transport

10 of 47

2.47

9.19

7.54e-21

GO:0006122

Mitochondrial electron transport, ubiquinol to cytochrome c

6 of 12

2.84

6.64

2.44e-13

GO:0006123

Mitochondrial electron transport, cytochrome c to oxygen

4 of 10

2.75

3.84

6.75e-08

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009055

Electron transfer activity

5 of 47

2.17

3.17

3.26e-07

GO:0015453

Oxidoreduction-driven active transmembrane transporter activity

4 of 35

2.2

2.51

1.13e-05

GO:0015078

Proton transmembrane transporter activity

3 of 54

1.89

1.27

0.0031

GO:0008121

Ubiquinol-cytochrome-c reductase activity

2 of 7

2.6

1.27

0.0047

GO:0016491

Oxidoreductase activity

6 of 577

1.16

1.05

0.00056

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070069

Cytochrome complex

10 of 26

2.73

11.22

1.18e-23

GO:0098803

Respiratory chain complex

11 of 61

2.4

9.85

1.18e-23

GO:0005746

Mitochondrial respirasome

11 of 61

2.4

9.85

1.18e-23

GO:0098800

Inner mitochondrial membrane protein complex

11 of 101

2.18

8.16

4.09e-22

GO:0005750

Mitochondrial respiratory chain complex III

6 of 12

2.84

7.06

3.62e-14

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:39354118

(2024) Novel fungicide and neonicotinoid insecticide impair flight behavior in pollen foraging honey bees, Apis mellifera.

3 of 7

2.78

1.97

0.00025

PMID:31182611

(2019) Loss of the HIF pathway in a widely distributed intertidal crustacean, the copepod Tigriopus californicus.

2 of 6

2.67

0.72

0.0491

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7906

Cytochrome complex

10 of 18

2.89

12.04

1.77e-24

CL:7841

Respiratory chain complex

11 of 55

2.44

10.21

4.72e-24

CL:7907

Respiratory chain complex III

7 of 11

2.95

8.53

6.41e-17

CL:7919

Respiratory chain complex III

4 of 5

3.05

4.58

3.96e-09

CL:7909

Respiratory chain complex III

3 of 5

2.92

3.01

3.09e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ame00190

Oxidative phosphorylation

11 of 86

2.25

8.83

4.86e-23

ame01100

Metabolic pathways

11 of 820

1.27

2.16

7.47e-13

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-611105

Respiratory electron transport

11 of 93

2.22

8.25

1.12e-21

MAP-163200

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

11 of 111

2.14

7.68

3.52e-21

MAP-1428517

The citric acid (TCA) cycle and respiratory electron transport

11 of 179

1.93

6.03

3.63e-19

MAP-9707564

Cytoprotection by HMOX1

4 of 52

2.03

2.36

1.42e-05

MAP-5628897

TP53 Regulates Metabolic Genes

4 of 72

1.89

2.06

4.11e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070069

Cytochrome complex

8 of 23

2.69

8.34

2.41e-17

GOCC:0070469

Respirasome

9 of 65

2.29

7.19

3.29e-17

GOCC:0005746

Mitochondrial respirasome

8 of 45

2.39

7.0

8.98e-16

GOCC:0098803

Respiratory chain complex

8 of 47

2.37

6.95

9.25e-16

GOCC:0005750

Mitochondrial respiratory chain complex III

5 of 10

2.84

5.66

2.29e-11

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0679

Respiratory chain

2 of 9

2.49

1.16

0.0074

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