SHC1 protein (Pygoscelis adeliae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

SHC1

SHC-transforming protein 1. (140 aa)

Predicted Functional Partners:

GRB2

0.993

EGFR

0.979

ERBB4

0.979

INSR

0.964

PTK2

0.920

SHC4

0.908

SHC3

0.904

MET

0.895

IGF1R

0.876

SOS1

0.837

Your Current Organism:

Pygoscelis adeliae

NCBI taxonomy Id: 9238
Other names: Adelie penguin, P. adeliae, Pygoscelis adelia

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGFR	ERBB4	A0A093NGD6	A0A093PA16	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.900
EGFR	GRB2	A0A093NGD6	A0A093NQ58	Receptor protein-tyrosine kinase.	Growth factor receptor-bound protein 2.	0.991
EGFR	MET	A0A093NGD6	A0A093R7W8	Receptor protein-tyrosine kinase.	Hepatocyte growth factor receptor.	0.866
EGFR	PTK2	A0A093NGD6	A0A093P7K3	Receptor protein-tyrosine kinase.	Focal adhesion kinase 1.	0.957
EGFR	SHC1	A0A093NGD6	A0A093PHF6	Receptor protein-tyrosine kinase.	SHC-transforming protein 1.	0.979
EGFR	SHC3	A0A093NGD6	A0A093PFM0	Receptor protein-tyrosine kinase.	SHC-transforming protein 3.	0.979
EGFR	SHC4	A0A093NGD6	A0A093PCP6	Receptor protein-tyrosine kinase.	SHC-transforming protein 4.	0.973
EGFR	SOS1	A0A093NGD6	A0A093QTU9	Receptor protein-tyrosine kinase.	Son of sevenless 1.	0.976
ERBB4	EGFR	A0A093PA16	A0A093NGD6	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.900
ERBB4	GRB2	A0A093PA16	A0A093NQ58	Receptor protein-tyrosine kinase.	Growth factor receptor-bound protein 2.	0.991
ERBB4	MET	A0A093PA16	A0A093R7W8	Receptor protein-tyrosine kinase.	Hepatocyte growth factor receptor.	0.866
ERBB4	PTK2	A0A093PA16	A0A093P7K3	Receptor protein-tyrosine kinase.	Focal adhesion kinase 1.	0.594
ERBB4	SHC1	A0A093PA16	A0A093PHF6	Receptor protein-tyrosine kinase.	SHC-transforming protein 1.	0.979
ERBB4	SHC3	A0A093PA16	A0A093PFM0	Receptor protein-tyrosine kinase.	SHC-transforming protein 3.	0.979
ERBB4	SHC4	A0A093PA16	A0A093PCP6	Receptor protein-tyrosine kinase.	SHC-transforming protein 4.	0.973
ERBB4	SOS1	A0A093PA16	A0A093QTU9	Receptor protein-tyrosine kinase.	Son of sevenless 1.	0.773
GRB2	EGFR	A0A093NQ58	A0A093NGD6	Growth factor receptor-bound protein 2.	Receptor protein-tyrosine kinase.	0.991
GRB2	ERBB4	A0A093NQ58	A0A093PA16	Growth factor receptor-bound protein 2.	Receptor protein-tyrosine kinase.	0.991
GRB2	IGF1R	A0A093NQ58	A0A093NMK6	Growth factor receptor-bound protein 2.	Tyrosine-protein kinase receptor.	0.955
GRB2	INSR	A0A093NQ58	A0A093NSW0	Growth factor receptor-bound protein 2.	Tyrosine-protein kinase receptor.	0.955

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

20

average node degree:

3.64

avg. local clustering coefficient:

0.859

expected number of edges:

11

PPI enrichment p-value:

0.0138

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007017

Microtubule-based process

9 of 105

1.87

4.42

6.39e-13

GO:0000226

Microtubule cytoskeleton organization

5 of 61

1.85

2.27

9.79e-06

GO:0007018

Microtubule-based movement

4 of 52

1.82

1.73

0.00022

GO:0044782

Cilium organization

3 of 17

2.18

1.65

0.00068

GO:0000278

Mitotic cell cycle

4 of 100

1.54

1.26

0.0013

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005200

Structural constituent of cytoskeleton

4 of 8

2.63

3.28

7.05e-07

GO:0019894

Kinesin binding

2 of 3

2.76

1.33

0.0039

GO:0008092

Cytoskeletal protein binding

4 of 101

1.53

1.12

0.0032

GO:0005525

GTP binding

4 of 118

1.47

1.06

0.0039

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015630

Microtubule cytoskeleton

9 of 123

1.8

4.18

5.26e-13

GO:0005874

Microtubule

6 of 65

1.9

3.31

1.40e-08

GO:0005929

Cilium

3 of 20

2.11

1.97

0.00013

GO:0097546

Ciliary base

2 of 3

2.76

1.77

0.00058

GO:0005815

Microtubule organizing center

3 of 31

1.92

1.67

0.00041

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:30410859

(2018) Transcriptome analysis of growth heterosis in pearl oyster Pinctada fucata martensii.

2 of 2

2.94

1.33

0.0040

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1062

Mixed, incl. Microtubule-based process, and Cilium

9 of 92

1.93

4.82

9.82e-14

CL:1168

Mixed, incl. EML4 and NUDC in mitotic spindle formation, and Cilium

5 of 30

2.16

3.27

1.72e-07

CL:1169

Mixed, incl. EML4 and NUDC in mitotic spindle formation, and CFA20 domain

4 of 25

2.14

2.57

6.83e-06

CL:1064

Dynein complex, and Intraflagellar transport

4 of 33

2.02

2.33

1.58e-05

CL:1105

Intraciliary transport particle, and Kinesin complex

3 of 12

2.33

2.11

9.78e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04145

Phagosome

4 of 45

1.88

2.12

2.84e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5617833

Cilium Assembly

7 of 33

2.26

5.3

3.50e-12

MAP-1852241

Organelle biogenesis and maintenance

7 of 51

2.07

4.56

2.81e-11

MAP-9648025

EML4 and NUDC in mitotic spindle formation

4 of 23

2.18

2.67

4.47e-06

MAP-2500257

Resolution of Sister Chromatid Cohesion

4 of 26

2.12

2.61

5.22e-06

MAP-5620924

Intraflagellar transport

3 of 10

2.41

2.75e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0015630

Microtubule cytoskeleton

7 of 114

1.72

2.96

1.30e-08

GOCC:0005874

Microtubule

4 of 21

2.22

2.74

3.63e-06

GOCC:0005875

Microtubule associated complex

3 of 36

1.86

1.49

0.00092

GOCC:0005871

Kinesin complex

2 of 13

2.12

1.06

0.0103

GOCC:0043232

Intracellular non-membrane-bounded organelle

8 of 687

1.0

1.05

1.37e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0493

Microtubule

5 of 23

2.27

3.83

1.61e-08

KW-0206

Cytoskeleton

3 of 10

2.41

2.43

2.52e-05

KW-0342

GTP-binding

4 of 41

1.92

2.25

1.63e-05

KW-0547

Nucleotide-binding

5 of 462

0.97

0.7

0.0059

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017975

Tubulin, conserved site

4 of 6

2.76

3.32

6.97e-07

IPR037103

Tubulin/FtsZ-like, C-terminal domain

4 of 7

2.69

3.3

6.97e-07

IPR018316

Tubulin/FtsZ, 2-layer sandwich domain

4 of 7

2.69

3.3

6.97e-07

IPR000217

Tubulin

4 of 7

2.69

3.3

6.97e-07

IPR008280

Tubulin/FtsZ, C-terminal

4 of 8

2.63

3.28

6.97e-07

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00865

Tubulin/FtsZ family, C-terminal domain

4 of 6

2.76

3.83

7.15e-08

SM00864

Tubulin/FtsZ family, GTPase domain

4 of 7

2.69

3.81

7.15e-08

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