STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
WHSC1L1Histone-lysine N-methyltransferase NSD3. (1440 aa)    
Predicted Functional Partners:
PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1.
    
 0.909
CAMKMT
Calmodulin-lysine N-methyltransferase.
     
 0.904
EED
Polycomb protein EED.
   
 0.656
AS28_12568
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
    
 0.638
MPHOSPH8
M-phase phosphoprotein 8.
    
 0.635
ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2.
    
 0.632
RBBP5
Retinoblastoma-binding protein 5.
    
 0.630
BARD1
BRCA1-associated RING domain protein 1.
   
 0.583
SETD3
Protein-histidine N-methyltransferase.
     
 0.578
SUZ12
Polycomb protein SUZ12.
    
 0.572
Your Current Organism:
Pygoscelis adeliae
NCBI taxonomy Id: 9238
Other names: Adelie penguin, P. adeliae, Pygoscelis adelia
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.