Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
N300_10260Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (993 aa)    
Predicted Functional Partners:
N300_07212
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
   
  0.995
N300_09585
Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.
   
 0.992
N300_08751
Calcineurin subunit B type 1.
   
 0.865
N300_02245
Serine/threonine-protein phosphatase.
   
 0.829
N300_11797
Serine/threonine-protein phosphatase.
   
 0.829
N300_14631
Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.
    
 0.825
N300_15032
Nuclear receptor ROR-alpha.
     
  0.816
N300_03285
Phosphoinositide phospholipase C.
     
 0.787
N300_03420
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.
     
 0.787
N300_04131
GDT1 family protein.
   
 
 0.758
Your Current Organism:
Calypte anna
NCBI taxonomy Id: 9244
Other names: C. anna
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