N300_15337 protein (Calypte anna) - STRING interaction network

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second shell of interactors

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Edges:

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Score

N300_15337

Ribonucleoside-diphosphate reductase subunit M2. (326 aa)

Predicted Functional Partners:

N300_10782

0.997

N300_07023

0.876

N300_07022

0.876

N300_15888

0.858

N300_04817

0.856

N300_03959

0.846

N300_07682

0.846

N300_08601

0.840

N300_15415

0.840

N300_04422

0.837

Your Current Organism:

Calypte anna

NCBI taxonomy Id: 9244
Other names: C. anna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
N300_03959	N300_04817	A0A091ICG7	A0A091IIV5	Peripheral plasma membrane protein CASK.	Thioredoxin domain-containing protein 3.	0.880
N300_03959	N300_07022	A0A091ICG7	A0A091I9Y7	Peripheral plasma membrane protein CASK.	Adenylate kinase 9.	0.911
N300_03959	N300_07023	A0A091ICG7	A0A091HL18	Peripheral plasma membrane protein CASK.	Adenylate kinase 9.	0.911
N300_03959	N300_10782	A0A091ICG7	A0A091HPL3	Peripheral plasma membrane protein CASK.	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.915
N300_03959	N300_15337	A0A091ICG7	A0A091HL37	Peripheral plasma membrane protein CASK.	Ribonucleoside-diphosphate reductase subunit M2.	0.846
N300_03959	N300_15415	A0A091ICG7	A0A091HY44	Peripheral plasma membrane protein CASK.	ADK_lid domain-containing protein; Belongs to the adenylate kinase family.	0.752
N300_04422	N300_08601	A0A091HGD7	A0A091HGL6	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
N300_04422	N300_10782	A0A091HGD7	A0A091HPL3	DNA helicase; Belongs to the MCM family.	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.945
N300_04422	N300_15337	A0A091HGD7	A0A091HL37	DNA helicase; Belongs to the MCM family.	Ribonucleoside-diphosphate reductase subunit M2.	0.837
N300_04817	N300_03959	A0A091IIV5	A0A091ICG7	Thioredoxin domain-containing protein 3.	Peripheral plasma membrane protein CASK.	0.880
N300_04817	N300_07022	A0A091IIV5	A0A091I9Y7	Thioredoxin domain-containing protein 3.	Adenylate kinase 9.	0.954
N300_04817	N300_07023	A0A091IIV5	A0A091HL18	Thioredoxin domain-containing protein 3.	Adenylate kinase 9.	0.954
N300_04817	N300_07682	A0A091IIV5	A0A091ITN5	Thioredoxin domain-containing protein 3.	Thymidylate_kin domain-containing protein.	0.902
N300_04817	N300_10782	A0A091IIV5	A0A091HPL3	Thioredoxin domain-containing protein 3.	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.940
N300_04817	N300_15337	A0A091IIV5	A0A091HL37	Thioredoxin domain-containing protein 3.	Ribonucleoside-diphosphate reductase subunit M2.	0.856
N300_04817	N300_15415	A0A091IIV5	A0A091HY44	Thioredoxin domain-containing protein 3.	ADK_lid domain-containing protein; Belongs to the adenylate kinase family.	0.845
N300_04817	N300_15888	A0A091IIV5	A0A091IFP8	Thioredoxin domain-containing protein 3.	Thymidylate kinase.	0.902
N300_07022	N300_03959	A0A091I9Y7	A0A091ICG7	Adenylate kinase 9.	Peripheral plasma membrane protein CASK.	0.911
N300_07022	N300_04817	A0A091I9Y7	A0A091IIV5	Adenylate kinase 9.	Thioredoxin domain-containing protein 3.	0.954
N300_07022	N300_07023	A0A091I9Y7	A0A091HL18	Adenylate kinase 9.	Adenylate kinase 9.	0.999

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Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.79

expected number of edges:

11

PPI enrichment p-value:

3.02e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000398

mRNA splicing, via spliceosome

11 of 187

1.93

5.85

2.82e-18

GO:0000245

Spliceosomal complex assembly

5 of 47

2.19

3.62

2.96e-08

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

8 of 592

1.29

1.68

8.66e-07

GO:0030620

U2 snRNA binding

2 of 4

2.86

1.37

0.0033

GO:0003676

Nucleic acid binding

9 of 1578

0.92

0.9

3.24e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005686

U2 snRNP

9 of 23

2.75

10.08

6.74e-21

GO:0005681

Spliceosomal complex

11 of 150

2.03

6.79

3.16e-20

GO:0005684

U2-type spliceosomal complex

7 of 64

2.2

5.39

8.36e-13

GO:0071004

U2-type prespliceosome

6 of 39

2.35

5.22

1.45e-11

GO:0071011

Precatalytic spliceosome

4 of 15

2.59

3.94

3.16e-08

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:13483

U2 snRNP

10 of 11

3.12

13.41

2.81e-26

CL:13485

U2 snRNP

6 of 6

3.16

7.83

3.29e-15

CL:13420

mRNA Splicing

11 of 146

2.04

6.93

1.63e-20

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03040

Spliceosome

11 of 219

1.86

5.58

6.79e-19

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72172

mRNA Splicing

11 of 163

1.99

6.42

1.79e-19

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

11 of 267

1.78

4.87

1.75e-17

MAP-72163

mRNA Splicing - Major Pathway

8 of 146

1.9

4.38

2.38e-12

MAP-8953854

Metabolism of RNA

11 of 678

1.37

2.55

2.85e-13

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005681

Spliceosomal complex

9 of 96

2.13

6.17

8.48e-16

GOCC:0005689

U12-type spliceosomal complex

4 of 5

3.06

4.6

3.66e-09

GOCC:0071004

U2-type prespliceosome

4 of 17

2.53

3.59

1.39e-07

GOCC:1990904

Ribonucleoprotein complex

10 of 438

1.52

3.04

1.42e-12

GOCC:0005686

U2 snRNP

3 of 8

2.73

2.9

4.24e-06

(more ...)

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