node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BLM | ERCC4 | ENSOANP00000014820 | ENSOANP00000025598 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. | ERCC excision repair 4, endonuclease catalytic subunit. | 0.842 |
BLM | F6YT00_ORNAN | ENSOANP00000014820 | ENSOANP00000016296 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. | WD_REPEATS_REGION domain-containing protein. | 0.977 |
BLM | FAN1 | ENSOANP00000014820 | ENSOANP00000016444 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. | 0.551 |
BLM | FANCM | ENSOANP00000014820 | ENSOANP00000022071 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. | Uncharacterized protein. | 0.999 |
BLM | FEN1 | ENSOANP00000014820 | ENSOANP00000012510 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.863 |
BLM | HELQ | ENSOANP00000014820 | ENSOANP00000003355 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. | Uncharacterized protein. | 0.606 |
BLM | MRE11 | ENSOANP00000014820 | ENSOANP00000016491 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.929 |
BLM | TOP3B | ENSOANP00000014820 | ENSOANP00000031381 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.960 |
ERCC4 | BLM | ENSOANP00000025598 | ENSOANP00000014820 | ERCC excision repair 4, endonuclease catalytic subunit. | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. | 0.842 |
ERCC4 | F6YT00_ORNAN | ENSOANP00000025598 | ENSOANP00000016296 | ERCC excision repair 4, endonuclease catalytic subunit. | WD_REPEATS_REGION domain-containing protein. | 0.786 |
ERCC4 | FAN1 | ENSOANP00000025598 | ENSOANP00000016444 | ERCC excision repair 4, endonuclease catalytic subunit. | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. | 0.754 |
ERCC4 | FANCL | ENSOANP00000025598 | ENSOANP00000017703 | ERCC excision repair 4, endonuclease catalytic subunit. | FA complementation group L. | 0.912 |
ERCC4 | FANCM | ENSOANP00000025598 | ENSOANP00000022071 | ERCC excision repair 4, endonuclease catalytic subunit. | Uncharacterized protein. | 0.776 |
ERCC4 | FEN1 | ENSOANP00000025598 | ENSOANP00000012510 | ERCC excision repair 4, endonuclease catalytic subunit. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.761 |
ERCC4 | HELQ | ENSOANP00000025598 | ENSOANP00000003355 | ERCC excision repair 4, endonuclease catalytic subunit. | Uncharacterized protein. | 0.608 |
ERCC4 | MRE11 | ENSOANP00000025598 | ENSOANP00000016491 | ERCC excision repair 4, endonuclease catalytic subunit. | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.741 |
ERCC4 | PARP1 | ENSOANP00000025598 | ENSOANP00000002367 | ERCC excision repair 4, endonuclease catalytic subunit. | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. | 0.608 |
ERCC4 | TOP3B | ENSOANP00000025598 | ENSOANP00000031381 | ERCC excision repair 4, endonuclease catalytic subunit. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.628 |
F6YT00_ORNAN | BLM | ENSOANP00000016296 | ENSOANP00000014820 | WD_REPEATS_REGION domain-containing protein. | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. | 0.977 |
F6YT00_ORNAN | ERCC4 | ENSOANP00000016296 | ENSOANP00000025598 | WD_REPEATS_REGION domain-containing protein. | ERCC excision repair 4, endonuclease catalytic subunit. | 0.786 |