HDAC8 protein (Ornithorhynchus anatinus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARID4A	ARID4B	ENSOANP00000018754	ENSOANP00000027692	AT-rich interaction domain 4A.	ARID domain-containing protein.	0.951
ARID4A	F6Z6X1_ORNAN	ENSOANP00000018754	ENSOANP00000001930	AT-rich interaction domain 4A.	ARID domain-containing protein.	0.951
ARID4A	F7EV44_ORNAN	ENSOANP00000018754	ENSOANP00000014148	AT-rich interaction domain 4A.	Uncharacterized protein.	0.533
ARID4A	H2AZ2	ENSOANP00000018754	ENSOANP00000014916	AT-rich interaction domain 4A.	Histone H2A; Belongs to the histone H2A family.	0.869
ARID4A	HDAC8	ENSOANP00000018754	ENSOANP00000004686	AT-rich interaction domain 4A.	Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.851
ARID4A	KDM1A	ENSOANP00000018754	ENSOANP00000006331	AT-rich interaction domain 4A.	Lysine demethylase 1A.	0.521
ARID4A	MACROH2A1	ENSOANP00000018754	ENSOANP00000023437	AT-rich interaction domain 4A.	Histone H2A; Belongs to the histone H2A family.	0.574
ARID4A	MACROH2A2	ENSOANP00000018754	ENSOANP00000019238	AT-rich interaction domain 4A.	H2A histone family member Y2; Belongs to the histone H2A family.	0.574
ARID4A	SAP30	ENSOANP00000018754	ENSOANP00000018210	AT-rich interaction domain 4A.	Sin3A associated protein 30.	0.978
ARID4A	SIN3A	ENSOANP00000018754	ENSOANP00000016807	AT-rich interaction domain 4A.	SIN3 transcription regulator family member A.	0.874
ARID4B	ARID4A	ENSOANP00000027692	ENSOANP00000018754	ARID domain-containing protein.	AT-rich interaction domain 4A.	0.951
ARID4B	F6Z6X1_ORNAN	ENSOANP00000027692	ENSOANP00000001930	ARID domain-containing protein.	ARID domain-containing protein.	0.681
ARID4B	F7EV44_ORNAN	ENSOANP00000027692	ENSOANP00000014148	ARID domain-containing protein.	Uncharacterized protein.	0.524
ARID4B	H2AZ2	ENSOANP00000027692	ENSOANP00000014916	ARID domain-containing protein.	Histone H2A; Belongs to the histone H2A family.	0.869
ARID4B	HDAC8	ENSOANP00000027692	ENSOANP00000004686	ARID domain-containing protein.	Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.851
ARID4B	KDM1A	ENSOANP00000027692	ENSOANP00000006331	ARID domain-containing protein.	Lysine demethylase 1A.	0.511
ARID4B	MACROH2A1	ENSOANP00000027692	ENSOANP00000023437	ARID domain-containing protein.	Histone H2A; Belongs to the histone H2A family.	0.578
ARID4B	MACROH2A2	ENSOANP00000027692	ENSOANP00000019238	ARID domain-containing protein.	H2A histone family member Y2; Belongs to the histone H2A family.	0.574
ARID4B	SAP30	ENSOANP00000027692	ENSOANP00000018210	ARID domain-containing protein.	Sin3A associated protein 30.	0.960
ARID4B	SIN3A	ENSOANP00000027692	ENSOANP00000016807	ARID domain-containing protein.	SIN3 transcription regulator family member A.	0.875