STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (380 aa)    
Predicted Functional Partners:
FOS
Fos proto-oncogene, AP-1 transcription factor subunit.
   
 0.925
PRKACA
Protein kinase cAMP-activated catalytic subunit alpha.
   
 
 0.903
PRKACB
Uncharacterized protein.
   
 
 0.903
F7BD50_ORNAN
Uncharacterized protein.
    
 0.893
ETS1
ETS proto-oncogene 1, transcription factor; Transcription factor; Belongs to the ETS family.
   
 0.828
K7EHW0_ORNAN
Uncharacterized protein.
    
 0.785
SOX9
HMG box domain-containing protein.
   
 0.741
YES1
Tyrosine-protein kinase.
   
 
 0.723
ZFHX3
Zinc finger homeobox 3.
     
 0.707
ETS2
Protein C-ets-2; Transcription factor; Belongs to the ETS family.
   
 0.691
Your Current Organism:
Ornithorhynchus anatinus
NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.