STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TSG101SB domain-containing protein. (230 aa)    
Predicted Functional Partners:
VPS37B
VPS37B subunit of ESCRT-I.
   
 0.980
VPS28
VPS28 N-terminal domain-containing protein; Belongs to the VPS28 family.
   
 0.971
MVB12A
Multivesicular body subunit 12A.
    
 0.969
MVB12B
Multivesicular body subunit 12B.
    
 0.939
F6YY17_ORNAN
UEV domain-containing protein.
 
     0.926
F7BNL7_ORNAN
Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]
    
 0.913
RPS27A
Ribosomal protein S27a.
    
 0.911
VPS37A
VPS37 C-terminal domain-containing protein.
   
 0.900
CHMP6
Charged multivesicular body protein 6.
    
 0.899
VPS36
Vacuolar protein sorting 36 homolog.
    
 0.897
Your Current Organism:
Ornithorhynchus anatinus
NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus
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