F6ZX07_ORNAN protein (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

F6ZX07_ORNAN

Uncharacterized protein. (335 aa)

Predicted Functional Partners:

F7FSM0_ORNAN

0.938

ZNF280D

0.506

PHF20L1

0.442

CBX1

0.414

CBX3

0.414

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBX1	CBX3	ENSOANP00000006668	ENSOANP00000014578	Chromobox 1.	Chromobox 3.	0.766
CBX1	F6ZX07_ORNAN	ENSOANP00000006668	ENSOANP00000015032	Chromobox 1.	Uncharacterized protein.	0.414
CBX1	F7FSM0_ORNAN	ENSOANP00000006668	ENSOANP00000005503	Chromobox 1.	Uncharacterized protein.	0.414
CBX1	ZNF280D	ENSOANP00000006668	ENSOANP00000015030	Chromobox 1.	Uncharacterized protein.	0.414
CBX3	CBX1	ENSOANP00000014578	ENSOANP00000006668	Chromobox 3.	Chromobox 1.	0.766
CBX3	F6ZX07_ORNAN	ENSOANP00000014578	ENSOANP00000015032	Chromobox 3.	Uncharacterized protein.	0.414
CBX3	F7FSM0_ORNAN	ENSOANP00000014578	ENSOANP00000005503	Chromobox 3.	Uncharacterized protein.	0.414
CBX3	ZNF280D	ENSOANP00000014578	ENSOANP00000015030	Chromobox 3.	Uncharacterized protein.	0.414
F6ZX07_ORNAN	CBX1	ENSOANP00000015032	ENSOANP00000006668	Uncharacterized protein.	Chromobox 1.	0.414
F6ZX07_ORNAN	CBX3	ENSOANP00000015032	ENSOANP00000014578	Uncharacterized protein.	Chromobox 3.	0.414
F6ZX07_ORNAN	F7FSM0_ORNAN	ENSOANP00000015032	ENSOANP00000005503	Uncharacterized protein.	Uncharacterized protein.	0.938
F6ZX07_ORNAN	PHF20L1	ENSOANP00000015032	ENSOANP00000015959	Uncharacterized protein.	PHD finger protein 20 like 1.	0.442
F6ZX07_ORNAN	ZNF280D	ENSOANP00000015032	ENSOANP00000015030	Uncharacterized protein.	Uncharacterized protein.	0.506
F7FSM0_ORNAN	CBX1	ENSOANP00000005503	ENSOANP00000006668	Uncharacterized protein.	Chromobox 1.	0.414
F7FSM0_ORNAN	CBX3	ENSOANP00000005503	ENSOANP00000014578	Uncharacterized protein.	Chromobox 3.	0.414
F7FSM0_ORNAN	F6ZX07_ORNAN	ENSOANP00000005503	ENSOANP00000015032	Uncharacterized protein.	Uncharacterized protein.	0.938
F7FSM0_ORNAN	PHF20L1	ENSOANP00000005503	ENSOANP00000015959	Uncharacterized protein.	PHD finger protein 20 like 1.	0.442
F7FSM0_ORNAN	ZNF280D	ENSOANP00000005503	ENSOANP00000015030	Uncharacterized protein.	Uncharacterized protein.	0.817
PHF20L1	F6ZX07_ORNAN	ENSOANP00000015959	ENSOANP00000015032	PHD finger protein 20 like 1.	Uncharacterized protein.	0.442
PHF20L1	F7FSM0_ORNAN	ENSOANP00000015959	ENSOANP00000005503	PHD finger protein 20 like 1.	Uncharacterized protein.	0.442

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

37

average node degree:

6.73

avg. local clustering coefficient:

0.701

expected number of edges:

10

PPI enrichment p-value:

7.98e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006352

DNA-templated transcription, initiation

11 of 24

2.26

8.41

1.92e-21

GO:0050896

Response to stimulus

11 of 334

1.11

1.61

2.89e-11

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016987

Sigma factor activity

11 of 24

2.26

8.48

1.09e-21

GO:0003677

DNA binding

11 of 369

1.07

1.45

3.36e-10

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 1196

0.56

0.49

8.24e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6080

RNA polymerase sigma-70 like, and Sigma factor antagonist activity

10 of 35

2.05

6.17

5.00e-17

CL:6082

RNA polymerase sigma-70 like, and Sigma factor antagonist activity

8 of 28

2.05

5.1

3.69e-13

CL:6084

RNA polymerase sigma-70 like, and FecR protein

7 of 22

2.1

4.7

1.65e-11

CL:6109

Sigma-70, region 4

4 of 6

2.42

3.18

7.33e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

11 of 478

0.96

1.16

4.17e-09

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

11 of 55

1.9

5.74

1.17e-18

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0731

Sigma factor

11 of 22

2.3

8.94

1.53e-22

KW-0238

DNA-binding

11 of 178

1.39

2.67

4.04e-14

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04542

Sigma-70 region 2

10 of 19

2.32

8.05

2.09e-19

PF08281

Sigma-70, region 4

8 of 13

2.39

6.76

3.32e-15

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR007627

RNA polymerase sigma-70 region 2

11 of 20

2.34

9.0

4.97e-22

IPR039425

RNA polymerase sigma-70 like

11 of 21

2.32

8.89

4.97e-22

IPR014284

RNA polymerase sigma-70 like domain

11 of 22

2.3

8.78

4.97e-22

IPR013325

RNA polymerase sigma factor, region 2

11 of 22

2.3

8.78

4.97e-22

IPR013324

RNA polymerase sigma factor, region 3/4-like

11 of 22

2.3

8.78

4.97e-22

(more ...)

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