STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IL1R1Interleukin 1 receptor type 1. (573 aa)    
Predicted Functional Partners:
IL1B
Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.
   
 0.992
MYD88
MYD88 innate immune signal transduction adaptor.
    
 0.976
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.969
IRAK4
Protein kinase domain-containing protein.
    
 0.952
IL1RN
Interleukin-1.
   
 0.949
IL1R2
Uncharacterized protein.
   
 
0.931
IL1RAP
Interleukin 1 receptor accessory protein.
   
0.852
IRAK1
Interleukin 1 receptor associated kinase 1.
    
 0.715
IL1F10
Interleukin-1.
   
 0.709
F6U6U0_ORNAN
Interleukin-1.
   
 0.643
Your Current Organism:
Ornithorhynchus anatinus
NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus
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