F7FI48_ORNAN protein (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

F7FI48_ORNAN

Uncharacterized protein. (744 aa)

Predicted Functional Partners:

F7EXC7_ORNAN

0.947

GCN1

0.942

F6ZRV7_ORNAN

0.900

FAU

0.724

DRG2

0.710

RPS13

0.679

RPS15

0.674

F7AR12_ORNAN

0.656

RPS5

0.633

RPL15

0.633

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DRG2	F6ZRV7_ORNAN	ENSOANP00000010805	ENSOANP00000027627	Developmentally regulated GTP binding protein 2.	Uncharacterized protein.	0.710
DRG2	F7AR12_ORNAN	ENSOANP00000010805	ENSOANP00000003002	Developmentally regulated GTP binding protein 2.	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family.	0.675
DRG2	F7EXC7_ORNAN	ENSOANP00000010805	ENSOANP00000024710	Developmentally regulated GTP binding protein 2.	TOG domain-containing protein.	0.710
DRG2	F7FI48_ORNAN	ENSOANP00000010805	ENSOANP00000021234	Developmentally regulated GTP binding protein 2.	Uncharacterized protein.	0.710
DRG2	FAU	ENSOANP00000010805	ENSOANP00000018319	Developmentally regulated GTP binding protein 2.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.698
DRG2	GCN1	ENSOANP00000010805	ENSOANP00000007249	Developmentally regulated GTP binding protein 2.	Uncharacterized protein.	0.710
DRG2	RPL15	ENSOANP00000010805	ENSOANP00000019736	Developmentally regulated GTP binding protein 2.	Ribosomal protein L15; Belongs to the eukaryotic ribosomal protein eL15 family.	0.523
DRG2	RPS13	ENSOANP00000010805	ENSOANP00000012250	Developmentally regulated GTP binding protein 2.	Ribosomal protein S13; Belongs to the universal ribosomal protein uS15 family.	0.597
DRG2	RPS15	ENSOANP00000010805	ENSOANP00000022868	Developmentally regulated GTP binding protein 2.	Uncharacterized protein; Belongs to the universal ribosomal protein uS19 family.	0.669
DRG2	RPS5	ENSOANP00000010805	ENSOANP00000018894	Developmentally regulated GTP binding protein 2.	Ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family.	0.621
F6ZRV7_ORNAN	DRG2	ENSOANP00000027627	ENSOANP00000010805	Uncharacterized protein.	Developmentally regulated GTP binding protein 2.	0.710
F6ZRV7_ORNAN	F7AR12_ORNAN	ENSOANP00000027627	ENSOANP00000003002	Uncharacterized protein.	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family.	0.656
F6ZRV7_ORNAN	F7EXC7_ORNAN	ENSOANP00000027627	ENSOANP00000024710	Uncharacterized protein.	TOG domain-containing protein.	0.900
F6ZRV7_ORNAN	F7FI48_ORNAN	ENSOANP00000027627	ENSOANP00000021234	Uncharacterized protein.	Uncharacterized protein.	0.900
F6ZRV7_ORNAN	FAU	ENSOANP00000027627	ENSOANP00000018319	Uncharacterized protein.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.724
F6ZRV7_ORNAN	GCN1	ENSOANP00000027627	ENSOANP00000007249	Uncharacterized protein.	Uncharacterized protein.	0.900
F6ZRV7_ORNAN	RPL15	ENSOANP00000027627	ENSOANP00000019736	Uncharacterized protein.	Ribosomal protein L15; Belongs to the eukaryotic ribosomal protein eL15 family.	0.633
F6ZRV7_ORNAN	RPS13	ENSOANP00000027627	ENSOANP00000012250	Uncharacterized protein.	Ribosomal protein S13; Belongs to the universal ribosomal protein uS15 family.	0.676
F6ZRV7_ORNAN	RPS15	ENSOANP00000027627	ENSOANP00000022868	Uncharacterized protein.	Uncharacterized protein; Belongs to the universal ribosomal protein uS19 family.	0.674
F6ZRV7_ORNAN	RPS5	ENSOANP00000027627	ENSOANP00000018894	Uncharacterized protein.	Ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family.	0.631

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.84

expected number of edges:

13

PPI enrichment p-value:

1.45e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006281

DNA repair

8 of 69

1.64

2.93

2.15e-09

GO:0006284

Base-excision repair

3 of 11

2.01

1.66

0.00052

GO:0006259

DNA metabolic process

9 of 241

1.15

1.48

1.40e-07

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004527

Exonuclease activity

6 of 28

1.91

3.2

3.35e-08

GO:0004518

Nuclease activity

7 of 67

1.6

2.57

3.49e-08

GO:0008853

Exodeoxyribonuclease III activity

3 of 3

2.58

2.38

3.65e-05

GO:0140097

Catalytic activity, acting on DNA

9 of 127

1.43

2.37

1.35e-09

GO:0019104

DNA N-glycosylase activity

3 of 11

2.01

1.67

0.00049

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:737

AP endonuclease 1, and HhH-GPD domain

5 of 8

2.37

3.69

5.26e-08

CL:619

DNA repair, and DNA replication

7 of 69

1.58

2.47

7.37e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

xcv03410

Base excision repair

7 of 18

2.17

5.06

4.25e-12

xcv03030

DNA replication

2 of 15

1.7

0.67

0.0494

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0239

DNA-directed DNA polymerase

2 of 7

2.03

0.82

0.0284

KW-0227

DNA damage

3 of 36

1.5

0.74

0.0284

KW-0238

DNA-binding

5 of 216

0.94

0.55

0.0284

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03372

Endonuclease/Exonuclease/phosphatase family

3 of 9

2.1

1.41

0.0020

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR037493

Exodeoxyribonuclease III-like

3 of 3

2.58

1.81

0.00047

IPR023170

Helix-hairpin-helix, base-excision DNA repair, C-terminal

3 of 3

2.58

1.81

0.00047

IPR020847

AP endonuclease 1, binding site

3 of 3

2.58

1.81

0.00047

IPR004808

AP endonuclease 1

3 of 3

2.58

1.81

0.00047

IPR003265

HhH-GPD domain

3 of 4

2.45

1.79

0.00047

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00278

Helix-hairpin-helix DNA-binding motif class 1

2 of 7

2.03

0.79

0.0332

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (18%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About