STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMPRSS6Transmembrane serine protease 6; Belongs to the peptidase S1 family. (829 aa)    
Predicted Functional Partners:
HJV
Uncharacterized protein.
    
 
 0.794
DCN
Decorin; May affect the rate of fibrils formation.
   
 0.618
SLC11A2
Solute carrier family 11 member 2.
      
 0.598
NEO1
Neogenin 1.
      
 0.594
K7EF21_ORNAN
TGFb_propeptide domain-containing protein.
      
 0.567
TFRC
Uncharacterized protein.
   
  
 0.560
F7DYK2_ORNAN
Uncharacterized protein.
   
  
 0.549
ALAS2
5-aminolevulinate synthase.
    
 
 0.526
F7DQY6_ORNAN
Uncharacterized protein.
    
 0.497
MET
Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]
    
 0.497
Your Current Organism:
Ornithorhynchus anatinus
NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus
Server load: low (10%) [HD]