F7C6B2_ORNAN protein (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

F7C6B2_ORNAN

ZP domain-containing protein. (246 aa)

Predicted Functional Partners:

F6VPT7_ORNAN

0.915

F6S4T1_ORNAN

0.842

FCGBP

0.777

F6RJ46_ORNAN

0.662

F7E5S9_ORNAN

0.660

DPP4

0.587

ZNF593

0.581

ANPEP

0.574

F6YMD3_ORNAN

0.560

MAF1

0.560

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANPEP	DPP4	ENSOANP00000000604	ENSOANP00000009893	Aminopeptidase.	Uncharacterized protein; Belongs to the peptidase S9B family.	0.615
ANPEP	F7C6B2_ORNAN	ENSOANP00000000604	ENSOANP00000022546	Aminopeptidase.	ZP domain-containing protein.	0.574
DPP4	ANPEP	ENSOANP00000009893	ENSOANP00000000604	Uncharacterized protein; Belongs to the peptidase S9B family.	Aminopeptidase.	0.615
DPP4	F7C6B2_ORNAN	ENSOANP00000009893	ENSOANP00000022546	Uncharacterized protein; Belongs to the peptidase S9B family.	ZP domain-containing protein.	0.587
F6RJ46_ORNAN	F7C6B2_ORNAN	ENSOANP00000028761	ENSOANP00000022546	Uncharacterized protein.	ZP domain-containing protein.	0.662
F6S4T1_ORNAN	F7C6B2_ORNAN	ENSOANP00000018670	ENSOANP00000022546	VWFD domain-containing protein.	ZP domain-containing protein.	0.842
F6VPT7_ORNAN	F7C6B2_ORNAN	ENSOANP00000010031	ENSOANP00000022546	Uncharacterized protein.	ZP domain-containing protein.	0.915
F6YMD3_ORNAN	F7C6B2_ORNAN	ENSOANP00000016875	ENSOANP00000022546	Uncharacterized protein.	ZP domain-containing protein.	0.560
F7C6B2_ORNAN	ANPEP	ENSOANP00000022546	ENSOANP00000000604	ZP domain-containing protein.	Aminopeptidase.	0.574
F7C6B2_ORNAN	DPP4	ENSOANP00000022546	ENSOANP00000009893	ZP domain-containing protein.	Uncharacterized protein; Belongs to the peptidase S9B family.	0.587
F7C6B2_ORNAN	F6RJ46_ORNAN	ENSOANP00000022546	ENSOANP00000028761	ZP domain-containing protein.	Uncharacterized protein.	0.662
F7C6B2_ORNAN	F6S4T1_ORNAN	ENSOANP00000022546	ENSOANP00000018670	ZP domain-containing protein.	VWFD domain-containing protein.	0.842
F7C6B2_ORNAN	F6VPT7_ORNAN	ENSOANP00000022546	ENSOANP00000010031	ZP domain-containing protein.	Uncharacterized protein.	0.915
F7C6B2_ORNAN	F6YMD3_ORNAN	ENSOANP00000022546	ENSOANP00000016875	ZP domain-containing protein.	Uncharacterized protein.	0.560
F7C6B2_ORNAN	F7E5S9_ORNAN	ENSOANP00000022546	ENSOANP00000007037	ZP domain-containing protein.	Uncharacterized protein.	0.660
F7C6B2_ORNAN	FCGBP	ENSOANP00000022546	ENSOANP00000000630	ZP domain-containing protein.	Uncharacterized protein.	0.777
F7C6B2_ORNAN	MAF1	ENSOANP00000022546	ENSOANP00000023023	ZP domain-containing protein.	Repressor of RNA polymerase III transcription MAF1; Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA. Belongs to the MAF1 family.	0.560
F7C6B2_ORNAN	ZNF593	ENSOANP00000022546	ENSOANP00000019467	ZP domain-containing protein.	Zinc finger protein 593.	0.581
F7E5S9_ORNAN	F7C6B2_ORNAN	ENSOANP00000007037	ENSOANP00000022546	Uncharacterized protein.	ZP domain-containing protein.	0.660
FCGBP	F7C6B2_ORNAN	ENSOANP00000000630	ENSOANP00000022546	Uncharacterized protein.	ZP domain-containing protein.	0.777

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

54

PPI enrichment p-value:

0.095

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007165

Signal transduction

7 of 174

1.39

1.77

3.35e-06

GO:0000160

Phosphorelay signal transduction system

6 of 154

1.38

1.59

2.11e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016772

Transferase activity, transferring phosphorus-containing groups

6 of 307

1.08

0.85

0.0025

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2736

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain, and HPT domain superfamily

9 of 62

1.95

5.23

4.43e-15

CL:2723

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain, and HPT domain superfamily

10 of 85

1.86

5.03

5.10e-16

CL:2741

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain, and HPT domain superfamily

8 of 56

1.94

4.71

4.34e-13

CL:2747

PAS-associated, C-terminal, and HPT domain superfamily

7 of 40

2.03

4.59

9.94e-12

CL:2702

Signal transduction histidine kinase-related protein, C-terminal, and Signaling

11 of 135

1.7

4.25

4.99e-16

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

7 of 522

0.91

0.79

0.00059

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030428

Cell septum

3 of 11

2.22

1.83

0.00032

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

9 of 182

1.48

2.67

1.11e-10

KW-0418

Kinase

5 of 232

1.12

0.9

0.0021

KW-0902

Two-component regulatory system

2 of 19

1.81

0.75

0.0355

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001789

Signal transduction response regulator, receiver domain

9 of 174

1.5

2.63

6.23e-10

IPR011006

CheY-like superfamily

9 of 175

1.5

2.62

6.23e-10

IPR036641

HPT domain superfamily

3 of 7

2.42

2.11

0.00011

IPR003660

HAMP domain

3 of 17

2.03

1.62

0.00065

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

5 of 88

1.54

1.61

0.00011

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00448

cheY-homologous receiver domain

9 of 173

1.5

2.79

4.42e-11

SM00304

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain

3 of 18

2.01

1.91

0.00014

SM00388

His Kinase A (phosphoacceptor) domain

5 of 92

1.52

1.82

1.60e-05

SM00387

Histidine kinase-like ATPases

5 of 131

1.37

1.48

5.79e-05

SM00073

Histidine Phosphotransfer domain

2 of 6

2.31

1.47

0.0018

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (28%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About