STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MACROH2A1Histone H2A; Belongs to the histone H2A family. (289 aa)    
Predicted Functional Partners:
PARP1
Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.
    
 
 0.805
KDM6A
Uncharacterized protein.
  
 0.751
F6XRM8_ORNAN
Uncharacterized protein.
  
 0.736
LOC100093154
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
   
 0.706
H2AZ2
Histone H2A; Belongs to the histone H2A family.
   
0.706
F7FMX5_ORNAN
PWWP domain-containing protein.
    
 
 0.599
GLYR1
NAD_binding_11 domain-containing protein.
    
 
 0.599
F6XLV7_ORNAN
Uncharacterized protein.
    
 
 0.595
K7EFE3_ORNAN
WGR domain-containing protein.
    
 
 0.594
EED
Embryonic ectoderm development.
    
 0.587
Your Current Organism:
Ornithorhynchus anatinus
NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.