LOC100682014 protein (Ornithorhynchus anatinus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

LOC100682014

Uncharacterized protein. (738 aa)

Predicted Functional Partners:

GCLC

0.509

F6W1R1_ORNAN

0.509

KCNAB2

0.437

KCNAB3

0.437

KCNAB1

0.437

K7EER9_ORNAN

0.437

F6RSC9_ORNAN

0.425

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6RSC9_ORNAN	K7EER9_ORNAN	ENSOANP00000012075	ENSOANP00000032026	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Aldo_ket_red domain-containing protein.	0.436
F6RSC9_ORNAN	KCNAB1	ENSOANP00000012075	ENSOANP00000029752	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Aldo_ket_red domain-containing protein.	0.436
F6RSC9_ORNAN	KCNAB2	ENSOANP00000012075	ENSOANP00000013127	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Potassium voltage-gated channel subfamily A regulatory beta subunit 2.	0.436
F6RSC9_ORNAN	KCNAB3	ENSOANP00000012075	ENSOANP00000018511	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Potassium voltage-gated channel subfamily A regulatory beta subunit 3.	0.436
F6RSC9_ORNAN	LOC100682014	ENSOANP00000012075	ENSOANP00000028161	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Uncharacterized protein.	0.425
F6W1R1_ORNAN	LOC100682014	ENSOANP00000011870	ENSOANP00000028161	Uncharacterized protein.	Uncharacterized protein.	0.509
GCLC	LOC100682014	ENSOANP00000004547	ENSOANP00000028161	Glutamate-cysteine ligase catalytic subunit.	Uncharacterized protein.	0.509
K7EER9_ORNAN	F6RSC9_ORNAN	ENSOANP00000032026	ENSOANP00000012075	Aldo_ket_red domain-containing protein.	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.436
K7EER9_ORNAN	KCNAB1	ENSOANP00000032026	ENSOANP00000029752	Aldo_ket_red domain-containing protein.	Aldo_ket_red domain-containing protein.	0.521
K7EER9_ORNAN	LOC100682014	ENSOANP00000032026	ENSOANP00000028161	Aldo_ket_red domain-containing protein.	Uncharacterized protein.	0.437
KCNAB1	F6RSC9_ORNAN	ENSOANP00000029752	ENSOANP00000012075	Aldo_ket_red domain-containing protein.	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.436
KCNAB1	K7EER9_ORNAN	ENSOANP00000029752	ENSOANP00000032026	Aldo_ket_red domain-containing protein.	Aldo_ket_red domain-containing protein.	0.521
KCNAB1	LOC100682014	ENSOANP00000029752	ENSOANP00000028161	Aldo_ket_red domain-containing protein.	Uncharacterized protein.	0.437
KCNAB2	F6RSC9_ORNAN	ENSOANP00000013127	ENSOANP00000012075	Potassium voltage-gated channel subfamily A regulatory beta subunit 2.	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.436
KCNAB2	LOC100682014	ENSOANP00000013127	ENSOANP00000028161	Potassium voltage-gated channel subfamily A regulatory beta subunit 2.	Uncharacterized protein.	0.437
KCNAB3	F6RSC9_ORNAN	ENSOANP00000018511	ENSOANP00000012075	Potassium voltage-gated channel subfamily A regulatory beta subunit 3.	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.436
KCNAB3	LOC100682014	ENSOANP00000018511	ENSOANP00000028161	Potassium voltage-gated channel subfamily A regulatory beta subunit 3.	Uncharacterized protein.	0.437
LOC100682014	F6RSC9_ORNAN	ENSOANP00000028161	ENSOANP00000012075	Uncharacterized protein.	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.425
LOC100682014	F6W1R1_ORNAN	ENSOANP00000028161	ENSOANP00000011870	Uncharacterized protein.	Uncharacterized protein.	0.509
LOC100682014	GCLC	ENSOANP00000028161	ENSOANP00000004547	Uncharacterized protein.	Glutamate-cysteine ligase catalytic subunit.	0.509

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Network Stats

number of nodes:

11

number of edges:

49

average node degree:

8.91

avg. local clustering coefficient:

0.927

expected number of edges:

15

PPI enrichment p-value:

6.46e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 107

1.47

2.74

1.71e-11

GO:0010467

Gene expression

11 of 243

1.16

1.71

6.45e-11

GO:0044260

Cellular macromolecule metabolic process

11 of 479

0.86

0.95

5.49e-08

GO:0034641

Cellular nitrogen compound metabolic process

11 of 772

0.66

0.61

6.88e-06

GO:0044238

Primary metabolic process

11 of 1309

0.43

0.35

0.0014

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 54

1.77

4.35

1.63e-14

GO:0019843

rRNA binding

5 of 46

1.54

1.69

5.78e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

10 of 60

1.72

4.2

7.34e-15

GO:0044391

Ribosomal subunit

2 of 14

1.66

0.85

0.0194

GO:0005622

Intracellular anatomical structure

11 of 1318

0.42

0.36

0.00049

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:134

Ribosomal protein

9 of 42

1.83

4.51

5.89e-14

CL:128

Ribosomal protein

10 of 56

1.75

4.36

5.89e-15

CL:119

Ribosome, and Translation regulator activity

11 of 73

1.68

4.16

6.02e-16

CL:204

Structural constituent of ribosome

4 of 7

2.26

3.04

8.92e-07

CL:136

Ribosomal protein

3 of 32

1.47

0.97

0.0069

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

10 of 57

1.75

4.34

4.31e-15

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

9 of 52

1.74

3.89

1.19e-12

GOCC:0022626

Cytosolic ribosome

6 of 28

1.83

3.19

1.30e-08

GOCC:0044391

Ribosomal subunit

6 of 32

1.77

3.0

2.22e-08

GOCC:0022627

Cytosolic small ribosomal subunit

3 of 12

1.9

1.7

0.00032

GOCC:0022625

Cytosolic large ribosomal subunit

3 of 16

1.77

1.54

0.00055

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

10 of 56

1.75

4.34

7.12e-15

KW-0699

rRNA-binding

5 of 39

1.61

2.01

8.49e-06

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