DGCR8 protein (Ornithorhynchus anatinus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

DGCR8

Uncharacterized protein. (119 aa)

Predicted Functional Partners:

F7G9I3_ORNAN

0.992

F7G9J6_ORNAN

0.952

DICER1

0.850

ENSOANP00000032946

0.850

MRPL44

0.787

XPO5

0.776

DDX17

0.767

MECP2

0.744

METTL14

0.739

AGO2

0.725

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO2	DGCR8	ENSOANP00000011335	ENSOANP00000029265	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Uncharacterized protein.	0.725
AGO2	DICER1	ENSOANP00000011335	ENSOANP00000019062	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily.	0.951
AGO2	ENSOANP00000032946	ENSOANP00000011335	ENSOANP00000032946	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	annotation not available	0.927
AGO2	F7G9I3_ORNAN	ENSOANP00000011335	ENSOANP00000024814	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Uncharacterized protein.	0.825
AGO2	F7G9J6_ORNAN	ENSOANP00000011335	ENSOANP00000024811	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Uncharacterized protein.	0.669
AGO2	MRPL44	ENSOANP00000011335	ENSOANP00000015451	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Mitochondrial ribosomal protein L44.	0.628
AGO2	XPO5	ENSOANP00000011335	ENSOANP00000019172	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Xpo1 domain-containing protein.	0.737
DDX17	DGCR8	ENSOANP00000016747	ENSOANP00000029265	Uncharacterized protein; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.767
DDX17	F7G9I3_ORNAN	ENSOANP00000016747	ENSOANP00000024814	Uncharacterized protein; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.818
DDX17	F7G9J6_ORNAN	ENSOANP00000016747	ENSOANP00000024811	Uncharacterized protein; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.463
DGCR8	AGO2	ENSOANP00000029265	ENSOANP00000011335	Uncharacterized protein.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.725
DGCR8	DDX17	ENSOANP00000029265	ENSOANP00000016747	Uncharacterized protein.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.767
DGCR8	DICER1	ENSOANP00000029265	ENSOANP00000019062	Uncharacterized protein.	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily.	0.850
DGCR8	ENSOANP00000032946	ENSOANP00000029265	ENSOANP00000032946	Uncharacterized protein.	annotation not available	0.850
DGCR8	F7G9I3_ORNAN	ENSOANP00000029265	ENSOANP00000024814	Uncharacterized protein.	Uncharacterized protein.	0.992
DGCR8	F7G9J6_ORNAN	ENSOANP00000029265	ENSOANP00000024811	Uncharacterized protein.	Uncharacterized protein.	0.952
DGCR8	MECP2	ENSOANP00000029265	ENSOANP00000017465	Uncharacterized protein.	Methyl-CpG binding protein 2.	0.744
DGCR8	METTL14	ENSOANP00000029265	ENSOANP00000005246	Uncharacterized protein.	Methyltransferase like 14; Belongs to the MT-A70-like family.	0.739
DGCR8	MRPL44	ENSOANP00000029265	ENSOANP00000015451	Uncharacterized protein.	Mitochondrial ribosomal protein L44.	0.787
DGCR8	XPO5	ENSOANP00000029265	ENSOANP00000019172	Uncharacterized protein.	Xpo1 domain-containing protein.	0.776