K7E9K0_ORNAN protein (Ornithorhynchus anatinus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

K7E9K0_ORNAN

Uncharacterized protein. (94 aa)

Predicted Functional Partners:

INTS6

0.806

K7EAK1_ORNAN

0.655

INTS3

0.655

GTDC1

0.523

F7FQJ9_ORNAN

0.514

F6S1Z3_ORNAN

0.511

ZMYND8

0.478

ZMYND8-2

0.478

F6XLV7_ORNAN

0.415

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6S1Z3_ORNAN	F6XLV7_ORNAN	ENSOANP00000015171	ENSOANP00000013333	Uncharacterized protein.	Uncharacterized protein.	0.415
F6S1Z3_ORNAN	F7FQJ9_ORNAN	ENSOANP00000015171	ENSOANP00000007143	Uncharacterized protein.	WW domain-containing protein.	0.514
F6S1Z3_ORNAN	GTDC1	ENSOANP00000015171	ENSOANP00000018981	Uncharacterized protein.	Glycosyltransferase like domain containing 1.	0.523
F6S1Z3_ORNAN	INTS3	ENSOANP00000015171	ENSOANP00000032271	Uncharacterized protein.	Uncharacterized protein.	0.655
F6S1Z3_ORNAN	INTS6	ENSOANP00000015171	ENSOANP00000024468	Uncharacterized protein.	Integrator complex subunit 6.	0.806
F6S1Z3_ORNAN	K7E9K0_ORNAN	ENSOANP00000015171	ENSOANP00000030207	Uncharacterized protein.	Uncharacterized protein.	0.511
F6S1Z3_ORNAN	K7EAK1_ORNAN	ENSOANP00000015171	ENSOANP00000030558	Uncharacterized protein.	Uncharacterized protein.	0.655
F6S1Z3_ORNAN	ZMYND8	ENSOANP00000015171	ENSOANP00000019048	Uncharacterized protein.	Zinc finger MYND-type containing 8.	0.478
F6S1Z3_ORNAN	ZMYND8-2	ENSOANP00000015171	ENSOANP00000029386	Uncharacterized protein.	Protein kinase C-binding protein 1 isoform X9.	0.478
F6XLV7_ORNAN	F6S1Z3_ORNAN	ENSOANP00000013333	ENSOANP00000015171	Uncharacterized protein.	Uncharacterized protein.	0.415
F6XLV7_ORNAN	K7E9K0_ORNAN	ENSOANP00000013333	ENSOANP00000030207	Uncharacterized protein.	Uncharacterized protein.	0.415
F7FQJ9_ORNAN	F6S1Z3_ORNAN	ENSOANP00000007143	ENSOANP00000015171	WW domain-containing protein.	Uncharacterized protein.	0.514
F7FQJ9_ORNAN	GTDC1	ENSOANP00000007143	ENSOANP00000018981	WW domain-containing protein.	Glycosyltransferase like domain containing 1.	0.533
F7FQJ9_ORNAN	K7E9K0_ORNAN	ENSOANP00000007143	ENSOANP00000030207	WW domain-containing protein.	Uncharacterized protein.	0.514
GTDC1	F6S1Z3_ORNAN	ENSOANP00000018981	ENSOANP00000015171	Glycosyltransferase like domain containing 1.	Uncharacterized protein.	0.523
GTDC1	F7FQJ9_ORNAN	ENSOANP00000018981	ENSOANP00000007143	Glycosyltransferase like domain containing 1.	WW domain-containing protein.	0.533
GTDC1	K7E9K0_ORNAN	ENSOANP00000018981	ENSOANP00000030207	Glycosyltransferase like domain containing 1.	Uncharacterized protein.	0.523
INTS3	F6S1Z3_ORNAN	ENSOANP00000032271	ENSOANP00000015171	Uncharacterized protein.	Uncharacterized protein.	0.655
INTS3	INTS6	ENSOANP00000032271	ENSOANP00000024468	Uncharacterized protein.	Integrator complex subunit 6.	0.953
INTS3	K7E9K0_ORNAN	ENSOANP00000032271	ENSOANP00000030207	Uncharacterized protein.	Uncharacterized protein.	0.655

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

53

average node degree:

9.64

avg. local clustering coefficient:

0.962

expected number of edges:

11

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006606

Protein import into nucleus

4 of 36

2.13

2.67

5.40e-06

GO:0006913

Nucleocytoplasmic transport

5 of 106

1.76

2.34

4.31e-06

GO:0015031

Protein transport

8 of 431

1.35

1.87

3.82e-07

GO:0046907

Intracellular transport

8 of 481

1.31

1.76

3.82e-07

GO:0006886

Intracellular protein transport

5 of 273

1.35

1.33

0.00025

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005635

Nuclear envelope

3 of 74

1.69

0.87

0.0202

GO:0012505

Endomembrane system

6 of 894

0.91

0.57

0.0202

GO:0005634

Nucleus

8 of 2456

0.6

0.39

0.0218

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4901

Nuclear pore, and Nucleocytoplasmic carrier activity

6 of 68

2.03

3.6

1.51e-08

CL:4919

Nuclear pore, and Exportin-1/5

5 of 41

2.17

3.48

9.15e-08

CL:4980

Mixed, incl. Armadillo, and Ran binding domain

2 of 7

2.54

1.27

0.0056

CL:4921

Structural constituent of nuclear pore, and Nuclear pore

2 of 24

2.01

0.75

0.0441

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005643

Nuclear pore

4 of 47

2.02

2.15

5.34e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045255

Ran binding protein RanBP1-like

3 of 3

3.09

2.64

2.23e-05

IPR000156

Ran binding domain

3 of 4

2.96

2.63

2.23e-05

IPR011993

PH-like domain superfamily

3 of 50

1.86

1.09

0.0085

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00160

Ran-binding domain

3 of 4

2.96

3.02

4.41e-06

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