node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F6YT00_ORNAN | F7EIW2_ORNAN | ENSOANP00000016296 | ENSOANP00000014779 | WD_REPEATS_REGION domain-containing protein. | Ku_N domain-containing protein. | 0.773 |
F6YT00_ORNAN | FANCM | ENSOANP00000016296 | ENSOANP00000022071 | WD_REPEATS_REGION domain-containing protein. | Uncharacterized protein. | 0.896 |
F6YT00_ORNAN | FEN1 | ENSOANP00000016296 | ENSOANP00000012510 | WD_REPEATS_REGION domain-containing protein. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.903 |
F6YT00_ORNAN | K7EGF0_ORNAN | ENSOANP00000016296 | ENSOANP00000032607 | WD_REPEATS_REGION domain-containing protein. | 3'-5' exonuclease domain-containing protein. | 0.991 |
F6YT00_ORNAN | MEIOB | ENSOANP00000016296 | ENSOANP00000004638 | WD_REPEATS_REGION domain-containing protein. | Meiosis specific with OB-fold. | 0.804 |
F6YT00_ORNAN | RAD52 | ENSOANP00000016296 | ENSOANP00000020978 | WD_REPEATS_REGION domain-containing protein. | Uncharacterized protein. | 0.907 |
F6YT00_ORNAN | RPA1 | ENSOANP00000016296 | ENSOANP00000017238 | WD_REPEATS_REGION domain-containing protein. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.867 |
F6YT00_ORNAN | TOP3A | ENSOANP00000016296 | ENSOANP00000015659 | WD_REPEATS_REGION domain-containing protein. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.883 |
F6YT00_ORNAN | XRCC5 | ENSOANP00000016296 | ENSOANP00000029384 | WD_REPEATS_REGION domain-containing protein. | Ku_N domain-containing protein. | 0.855 |
F6YT00_ORNAN | XRCC6 | ENSOANP00000016296 | ENSOANP00000017950 | WD_REPEATS_REGION domain-containing protein. | SAP domain-containing protein. | 0.773 |
F7EIW2_ORNAN | F6YT00_ORNAN | ENSOANP00000014779 | ENSOANP00000016296 | Ku_N domain-containing protein. | WD_REPEATS_REGION domain-containing protein. | 0.773 |
F7EIW2_ORNAN | FANCM | ENSOANP00000014779 | ENSOANP00000022071 | Ku_N domain-containing protein. | Uncharacterized protein. | 0.635 |
F7EIW2_ORNAN | FEN1 | ENSOANP00000014779 | ENSOANP00000012510 | Ku_N domain-containing protein. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.678 |
F7EIW2_ORNAN | K7EGF0_ORNAN | ENSOANP00000014779 | ENSOANP00000032607 | Ku_N domain-containing protein. | 3'-5' exonuclease domain-containing protein. | 0.990 |
F7EIW2_ORNAN | MEIOB | ENSOANP00000014779 | ENSOANP00000004638 | Ku_N domain-containing protein. | Meiosis specific with OB-fold. | 0.644 |
F7EIW2_ORNAN | RAD52 | ENSOANP00000014779 | ENSOANP00000020978 | Ku_N domain-containing protein. | Uncharacterized protein. | 0.803 |
F7EIW2_ORNAN | RPA1 | ENSOANP00000014779 | ENSOANP00000017238 | Ku_N domain-containing protein. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.787 |
F7EIW2_ORNAN | TOP3A | ENSOANP00000014779 | ENSOANP00000015659 | Ku_N domain-containing protein. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.518 |
F7EIW2_ORNAN | XRCC5 | ENSOANP00000014779 | ENSOANP00000029384 | Ku_N domain-containing protein. | Ku_N domain-containing protein. | 0.973 |
F7EIW2_ORNAN | XRCC6 | ENSOANP00000014779 | ENSOANP00000017950 | Ku_N domain-containing protein. | SAP domain-containing protein. | 0.929 |