SPIRE1-2 protein (Ornithorhynchus anatinus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SPIRE1-2

KIND domain-containing protein. (100 aa)

Predicted Functional Partners:

GRAP2

0.800

F6PLS0_ORNAN

0.730

TOMM20

0.600

F7DBG2_ORNAN

0.556

K7E7K8_ORNAN

0.556

NCK1

0.534

F7FRJ2_ORNAN

0.534

NCK2

0.534

RAB11A

0.516

SPIRE2

0.513

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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structured XML interaction data, according to the 'PSI-MI' data standard

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... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6PLS0_ORNAN	F7DBG2_ORNAN	ENSOANP00000013236	ENSOANP00000019484	Uncharacterized protein.	Tyrosine-protein kinase.	0.817
F6PLS0_ORNAN	F7FRJ2_ORNAN	ENSOANP00000013236	ENSOANP00000005740	Uncharacterized protein.	SH3 domain-containing protein.	0.618
F6PLS0_ORNAN	GRAP2	ENSOANP00000013236	ENSOANP00000023109	Uncharacterized protein.	GRB2 related adaptor protein 2.	0.825
F6PLS0_ORNAN	K7E7K8_ORNAN	ENSOANP00000013236	ENSOANP00000029515	Uncharacterized protein.	Pkinase_Tyr domain-containing protein.	0.823
F6PLS0_ORNAN	NCK1	ENSOANP00000013236	ENSOANP00000000957	Uncharacterized protein.	NCK adaptor protein 1.	0.798
F6PLS0_ORNAN	NCK2	ENSOANP00000013236	ENSOANP00000022369	Uncharacterized protein.	Uncharacterized protein.	0.618
F6PLS0_ORNAN	SPIRE1-2	ENSOANP00000013236	ENSOANP00000032930	Uncharacterized protein.	KIND domain-containing protein.	0.730
F6PLS0_ORNAN	SPIRE2	ENSOANP00000013236	ENSOANP00000017601	Uncharacterized protein.	Spire type actin nucleation factor 2.	0.730
F7DBG2_ORNAN	F6PLS0_ORNAN	ENSOANP00000019484	ENSOANP00000013236	Tyrosine-protein kinase.	Uncharacterized protein.	0.817
F7DBG2_ORNAN	GRAP2	ENSOANP00000019484	ENSOANP00000023109	Tyrosine-protein kinase.	GRB2 related adaptor protein 2.	0.837
F7DBG2_ORNAN	K7E7K8_ORNAN	ENSOANP00000019484	ENSOANP00000029515	Tyrosine-protein kinase.	Pkinase_Tyr domain-containing protein.	0.403
F7DBG2_ORNAN	NCK1	ENSOANP00000019484	ENSOANP00000000957	Tyrosine-protein kinase.	NCK adaptor protein 1.	0.504
F7DBG2_ORNAN	SPIRE1-2	ENSOANP00000019484	ENSOANP00000032930	Tyrosine-protein kinase.	KIND domain-containing protein.	0.556
F7DBG2_ORNAN	SPIRE2	ENSOANP00000019484	ENSOANP00000017601	Tyrosine-protein kinase.	Spire type actin nucleation factor 2.	0.556
F7FRJ2_ORNAN	F6PLS0_ORNAN	ENSOANP00000005740	ENSOANP00000013236	SH3 domain-containing protein.	Uncharacterized protein.	0.618
F7FRJ2_ORNAN	GRAP2	ENSOANP00000005740	ENSOANP00000023109	SH3 domain-containing protein.	GRB2 related adaptor protein 2.	0.514
F7FRJ2_ORNAN	NCK1	ENSOANP00000005740	ENSOANP00000000957	SH3 domain-containing protein.	NCK adaptor protein 1.	0.957
F7FRJ2_ORNAN	NCK2	ENSOANP00000005740	ENSOANP00000022369	SH3 domain-containing protein.	Uncharacterized protein.	0.900
F7FRJ2_ORNAN	SPIRE1-2	ENSOANP00000005740	ENSOANP00000032930	SH3 domain-containing protein.	KIND domain-containing protein.	0.534
F7FRJ2_ORNAN	SPIRE2	ENSOANP00000005740	ENSOANP00000017601	SH3 domain-containing protein.	Spire type actin nucleation factor 2.	0.534

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.804

expected number of edges:

21

PPI enrichment p-value:

0.291

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051568

Histone H3-K4 methylation

6 of 11

2.61

5.33

4.55e-11

GO:0031497

Chromatin assembly

5 of 69

1.73

2.2

6.49e-06

GO:0006325

Chromatin organization

7 of 185

1.45

2.06

3.55e-07

GO:0051276

Chromosome organization

8 of 310

1.28

1.73

2.94e-07

GO:0034728

Nucleosome organization

3 of 29

1.89

1.37

0.0018

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030527

Structural constituent of chromatin

3 of 13

2.24

1.51

0.0014

GO:0046983

Protein dimerization activity

4 of 62

1.68

1.33

0.0014

GO:0046982

Protein heterodimerization activity

3 of 33

1.83

1.18

0.0045

GO:0042800

Histone methyltransferase activity (H3-K4 specific)

2 of 5

2.47

1.11

0.0093

GO:0042393

Histone binding

3 of 46

1.69

1.0

0.0093

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0048188

Set1C/COMPASS complex

6 of 8

2.75

6.05

2.65e-12

GO:0000786

Nucleosome

3 of 15

2.17

1.97

0.00015

GO:0017053

Transcription repressor complex

2 of 5

2.47

1.41

0.0025

GO:0005694

Chromosome

7 of 331

1.2

1.38

8.77e-06

GO:0032991

Protein-containing complex

11 of 1727

0.68

0.63

7.57e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:230

Mixed, incl. PKMTs methylate histone lysines, and Nucleosome

10 of 61

2.09

6.44

1.90e-17

CL:233

Mixed, incl. Structural constituent of chromatin, and Set1C/COMPASS complex

8 of 37

2.21

6.01

1.65e-14

CL:289

Set1C/COMPASS complex

5 of 5

2.87

5.48

5.39e-11

CL:235

Mixed, incl. Structural constituent of chromatin, and ISWI-type complex

3 of 21

2.03

1.7

0.00043

CL:342

Transcription repressor complex, and Activation of the AP-1 family of transcription factors

2 of 5

2.47

1.32

0.0038

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-4839726

Chromatin organization

6 of 78

1.76

2.62

3.88e-07

MAP-3247509

Chromatin modifying enzymes

6 of 78

1.76

2.62

3.88e-07

MAP-2299718

Condensation of Prophase Chromosomes

3 of 8

2.45

2.16

8.96e-05

MAP-3214858

RMTs methylate histone arginines

3 of 18

2.09

1.73

0.00043

MAP-8951664

Neddylation

4 of 64

1.67

1.57

0.00031

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0035097

Histone methyltransferase complex

5 of 14

2.43

3.97

1.64e-08

GOCC:0048188

Set1C/COMPASS complex

4 of 7

2.63

3.58

1.83e-07

GOCC:0000786

Nucleosome

3 of 16

2.15

1.75

0.00041

GOCC:0032991

Protein-containing complex

9 of 2102

0.5

0.36

0.0137

GOCC:0043229

Intracellular organelle

11 of 3525

0.37

0.29

0.0100

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0158

Chromosome

4 of 17

2.24

2.83

2.45e-06

KW-0544

Nucleosome core

3 of 7

2.5

2.53

1.77e-05

KW-0853

WD repeat

5 of 102

1.56

1.86

1.77e-05

KW-0539

Nucleus

4 of 331

0.95

0.51

0.0425

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001680

WD40 repeat

5 of 112

1.52

1.37

0.00060

IPR015943

WD40/YVTN repeat-like-containing domain superfamily

5 of 146

1.41

1.2

0.0011

IPR035425

CENP-T/Histone H4, histone fold

2 of 4

2.57

1.09

0.0105

IPR001951

Histone H4

2 of 3

2.7

1.09

0.0105

IPR009072

Histone-fold

3 of 31

1.86

1.04

0.0090

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00320

WD40 repeats

5 of 120

1.49

1.57

0.00010

SM00417

Histone H4

2 of 3

2.7

1.42

0.0026

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