BAL99905.1 protein (Caldilinea aerophila) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

BAL99905.1

Hypothetical protein. (359 aa)

Predicted Functional Partners:

BAL99904.1

0.707

BAL99903.1

0.675

BAL99319.1

0.616

BAL98590.1

0.577

BAM01729.1

0.478

BAM01546.1

0.454

BAM01164.1

0.453

BAM02099.1

0.442

nifU

0.441

BAL98392.1

0.430

Your Current Organism:

Caldilinea aerophila

NCBI taxonomy Id: 926550
Other names: C. aerophila DSM 14535 = NBRC 104270, Caldilinea aerophila DSM 14535, Caldilinea aerophila DSM 14535 = NBRC 104270, Caldilinea aerophila NBRC 104270, Caldilinea aerophila NBRC 104270 = DSM 14535, Caldilinea aerophila STL-6-O1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAL98392.1	BAL99319.1	CLDAP_03530	CLDAP_12800	Putative two-component hybrid sensor and regulator.	Putative PqqE homolog.	0.430
BAL98392.1	BAL99905.1	CLDAP_03530	CLDAP_18660	Putative two-component hybrid sensor and regulator.	Hypothetical protein.	0.430
BAL98392.1	BAM01546.1	CLDAP_03530	CLDAP_35060	Putative two-component hybrid sensor and regulator.	Putative two-component hybrid sensor and regulator.	0.999
BAL98392.1	BAM01729.1	CLDAP_03530	CLDAP_36890	Putative two-component hybrid sensor and regulator.	Putative pyruvate-ferredoxin oxidoreductase.	0.530
BAL98392.1	BAM02099.1	CLDAP_03530	CLDAP_40590	Putative two-component hybrid sensor and regulator.	Putative oxidoreductase.	0.430
BAL98590.1	BAL99905.1	CLDAP_05510	CLDAP_18660	Putative glycosyltransferase.	Hypothetical protein.	0.577
BAL99319.1	BAL98392.1	CLDAP_12800	CLDAP_03530	Putative PqqE homolog.	Putative two-component hybrid sensor and regulator.	0.430
BAL99319.1	BAL99904.1	CLDAP_12800	CLDAP_18650	Putative PqqE homolog.	Putative methyltransferase.	0.453
BAL99319.1	BAL99905.1	CLDAP_12800	CLDAP_18660	Putative PqqE homolog.	Hypothetical protein.	0.616
BAL99319.1	BAM01164.1	CLDAP_12800	CLDAP_31240	Putative PqqE homolog.	Hypothetical protein.	0.406
BAL99319.1	BAM01729.1	CLDAP_12800	CLDAP_36890	Putative PqqE homolog.	Putative pyruvate-ferredoxin oxidoreductase.	0.478
BAL99903.1	BAL99904.1	CLDAP_18640	CLDAP_18650	Putative methyltransferase.	Putative methyltransferase.	0.924
BAL99903.1	BAL99905.1	CLDAP_18640	CLDAP_18660	Putative methyltransferase.	Hypothetical protein.	0.675
BAL99903.1	BAM01164.1	CLDAP_18640	CLDAP_31240	Putative methyltransferase.	Hypothetical protein.	0.751
BAL99903.1	nifU	CLDAP_18640	CLDAP_18630	Putative methyltransferase.	Iron-sulfur cluster assembly protein.	0.526
BAL99904.1	BAL99319.1	CLDAP_18650	CLDAP_12800	Putative methyltransferase.	Putative PqqE homolog.	0.453
BAL99904.1	BAL99903.1	CLDAP_18650	CLDAP_18640	Putative methyltransferase.	Putative methyltransferase.	0.924
BAL99904.1	BAL99905.1	CLDAP_18650	CLDAP_18660	Putative methyltransferase.	Hypothetical protein.	0.707
BAL99904.1	BAM01164.1	CLDAP_18650	CLDAP_31240	Putative methyltransferase.	Hypothetical protein.	0.752
BAL99904.1	nifU	CLDAP_18650	CLDAP_18630	Putative methyltransferase.	Iron-sulfur cluster assembly protein.	0.526

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

11

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033611

Oxalate catabolic process

2 of 2

2.74

0.91

0.0225

GO:0022900

Electron transport chain

3 of 51

1.51

0.76

0.0263

GO:0006091

Generation of precursor metabolites and energy

4 of 98

1.35

0.74

0.0225

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016903

Oxidoreductase activity, acting on the aldehyde or oxo group of donors

3 of 15

2.04

1.5

0.0012

GO:0016491

Oxidoreductase activity

8 of 270

1.21

1.49

1.76e-06

GO:0051539

4 iron, 4 sulfur cluster binding

4 of 60

1.57

1.29

0.0012

GO:0030976

Thiamine pyrophosphate binding

2 of 11

2.0

0.84

0.0264

GO:0050136

NADH dehydrogenase (quinone) activity

2 of 18

1.79

0.69

0.0480

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1012

Mixed, incl. Generation of precursor metabolites and energy, and Valine, leucine and isoleucine biosynthesis

11 of 99

1.79

4.85

5.66e-17

CL:1017

Mixed, incl. 4Fe-4S binding domain, and 4Fe-4S dicluster domain

6 of 25

2.12

4.17

6.57e-10

CL:1015

Mixed, incl. Electron transport chain, and Cell redox homeostasis

7 of 42

1.96

4.13

8.96e-11

CL:1023

NADH dehydrogenase (ubiquinone) activity, and 4Fe-4S dicluster domain

5 of 14

2.29

3.95

9.60e-09

CL:1140

Oxalate catabolic process, and Thiamin diphosphate-binding fold

4 of 5

2.64

3.77

7.68e-08

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00020

Citrate cycle (TCA cycle)

7 of 18

2.33

5.86

3.02e-13

map00650

Butanoate metabolism

7 of 24

2.21

5.41

8.24e-13

map00620

Pyruvate metabolism

6 of 45

1.87

3.39

4.48e-09

map01200

Carbon metabolism

7 of 119

1.51

2.45

1.25e-08

map00010

Glycolysis / Gluconeogenesis

5 of 54

1.71

2.45

7.47e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990204

Oxidoreductase complex

3 of 40

1.62

0.9

0.0141

GOCC:0045272

Plasma membrane respiratory chain complex I

2 of 10

2.04

0.84

0.0262

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0670

Pyruvate

5 of 18

2.18

3.56

4.21e-08

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF17147

Pyruvate:ferredoxin oxidoreductase core domain II

2 of 3

2.57

0.92

0.0211

PF01855

Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg

2 of 3

2.57

0.92

0.0211

PF01558

Pyruvate ferredoxin/flavodoxin oxidoreductase

2 of 3

2.57

0.92

0.0211

PF01266

FAD dependent oxidoreductase

2 of 4

2.44

0.92

0.0211

PF12838

4Fe-4S dicluster domain

2 of 8

2.14

0.9

0.0211

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00928

NADH-ubiquinone oxidoreductase-F iron-sulfur binding region

2 of 3

2.57

1.29

0.0043

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