GCA_000515355_01932 protein (Promicromonospora kroppenstedtii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

GCA_000515355_01932

Unannotated protein. (333 aa)

Predicted Functional Partners:

GCA_000515355_00951

0.804

GCA_000515355_00952

0.799

GCA_000515355_01933

0.789

GCA_000515355_01763

0.774

GCA_000515355_01931

0.774

GCA_000515355_01684

0.682

GCA_000515355_04151

0.636

GCA_000515355_00003

0.634

GCA_000515355_00044

0.634

GCA_000515355_00736

0.634

Your Current Organism:

Promicromonospora kroppenstedtii

NCBI taxonomy Id: 926564
Other names: P. kroppenstedtii DSM 19349, Promicromonospora kroppenstedtii DSM 19349, Promicromonospora kroppenstedtii RS16

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structured XML interaction data, according to the 'PSI-MI' data standard

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... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
GCA_000515355_00003	GCA_000515355_01932	Unannotated protein.	Unannotated protein.	0.634
GCA_000515355_00044	GCA_000515355_01932	Unannotated protein.	Unannotated protein.	0.634
GCA_000515355_00736	GCA_000515355_01932	Unannotated protein.	Unannotated protein.	0.634
GCA_000515355_00951	GCA_000515355_00952	Unannotated protein.	Unannotated protein.	0.978
GCA_000515355_00951	GCA_000515355_01763	Unannotated protein.	Unannotated protein.	0.789
GCA_000515355_00951	GCA_000515355_01931	Unannotated protein.	Unannotated protein.	0.781
GCA_000515355_00951	GCA_000515355_01932	Unannotated protein.	Unannotated protein.	0.804
GCA_000515355_00952	GCA_000515355_00951	Unannotated protein.	Unannotated protein.	0.978
GCA_000515355_00952	GCA_000515355_01763	Unannotated protein.	Unannotated protein.	0.783
GCA_000515355_00952	GCA_000515355_01931	Unannotated protein.	Unannotated protein.	0.773
GCA_000515355_00952	GCA_000515355_01932	Unannotated protein.	Unannotated protein.	0.799
GCA_000515355_01684	GCA_000515355_01932	Unannotated protein.	Unannotated protein.	0.682
GCA_000515355_01763	GCA_000515355_00951	Unannotated protein.	Unannotated protein.	0.789
GCA_000515355_01763	GCA_000515355_00952	Unannotated protein.	Unannotated protein.	0.783
GCA_000515355_01763	GCA_000515355_01931	Unannotated protein.	Unannotated protein.	0.777
GCA_000515355_01763	GCA_000515355_01932	Unannotated protein.	Unannotated protein.	0.774
GCA_000515355_01931	GCA_000515355_00951	Unannotated protein.	Unannotated protein.	0.781
GCA_000515355_01931	GCA_000515355_00952	Unannotated protein.	Unannotated protein.	0.773
GCA_000515355_01931	GCA_000515355_01763	Unannotated protein.	Unannotated protein.	0.777
GCA_000515355_01931	GCA_000515355_01932	Unannotated protein.	Unannotated protein.	0.774

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

48

PPI enrichment p-value:

0.0411

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006457

Protein folding

7 of 19

1.93

3.65

1.72e-09

GO:0009408

Response to heat

5 of 9

2.11

3.0

5.64e-07

GO:0042026

Protein refolding

2 of 3

2.18

0.82

0.0305

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005515

Protein binding

6 of 29

1.68

2.35

1.11e-06

GO:0051082

Unfolded protein binding

4 of 10

1.96

2.27

1.77e-05

GO:0016887

ATP hydrolysis activity

4 of 41

1.35

1.16

0.00099

GO:0031072

Heat shock protein binding

2 of 4

2.06

1.16

0.0063

GO:0030554

Adenyl nucleotide binding

10 of 294

0.89

0.94

1.51e-06

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 875

0.46

0.38

0.0010

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:398

Protein folding, and ATP-dependent peptidase activity

8 of 22

1.92

4.26

1.29e-11

CL:400

Stress response, and Protein folding chaperone

7 of 15

2.03

4.25

1.19e-10

CL:403

Stress response, and Protein folding chaperone

4 of 8

2.06

2.33

1.78e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0346

Stress response

5 of 7

2.21

3.47

7.84e-08

KW-0143

Chaperone

5 of 13

1.95

2.88

4.19e-07

KW-0677

Repeat

3 of 10

1.84

1.45

0.0011

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02861

Clp amino terminal domain, pathogenicity island component

2 of 2

2.36

0.76

0.0400

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003959

ATPase, AAA-type, core

3 of 7

1.99

1.2

0.0049

IPR041546

ClpA/ClpB, AAA lid domain

2 of 2

2.36

0.79

0.0352

IPR036869

Chaperone J-domain superfamily

2 of 3

2.18

0.79

0.0352

IPR036628

Clp, N-terminal domain superfamily

2 of 2

2.36

0.79

0.0352

IPR028299

ClpA/B, conserved site 2

2 of 2

2.36

0.79

0.0352

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01086

C-terminal, D2-small domain, of ClpB protein

2 of 4

2.06

0.87

0.0232

SM00271

DnaJ molecular chaperone homology domain

2 of 4

2.06

0.87

0.0232

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