STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AIC14407.1Beta propeller domain containing protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative membrane component. (766 aa)    
Predicted Functional Partners:
fen
Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...]
  
 0.848
topA
DNA topoisomerase IA; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA sup [...]
    
 0.792
rpl1p
50S ribosomal protein L1p; Binds directly to 23S rRNA. Probably involved in E site tRNA release.
    
 0.725
AIC14511.1
Putative transposase IS3/IS911 family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
    
  0.724
AIC15202.1
Putative nucleic acid binding OB-fold tRNA/helicase-type; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; cell process.
  
 
 0.715
AIC16734.1
RPA-like protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; cell process.
  
 
 0.610
AIC14324.1
Putative helicase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.
   
 0.543
xpb
Putative DNA repair helicase XPB; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
   
 0.543
AIC15141.1
Helicase domain protein.
    
 0.541
AIC14408.1
Hypothetical protein; No homology to any previously reported sequences.
       0.489
Your Current Organism:
Nitrososphaera viennensis
NCBI taxonomy Id: 926571
Other names: Candidatus Nitrososphaera sp. EN76, N. viennensis EN76, Nitrososphaera viennensis EN76, Nitrososphaera viennensis str. EN76, Nitrososphaera viennensis strain EN76
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.