STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
topADNA topoisomerase IA; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA sup [...] (697 aa)    
Predicted Functional Partners:
AIC15933.1
Putative DNA double-strand break repair Rad50 ATPase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
 0.883
mre11
Putative DNA double-strand break repair protein Mre11; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family.
 
 0.847
fen
Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...]
 
 0.828
xpf
Putative DNA repair nuclease XPF; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
    
 0.792
AIC14407.1
Beta propeller domain containing protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative membrane component.
    
 0.792
AIC15202.1
Putative nucleic acid binding OB-fold tRNA/helicase-type; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; cell process.
  
 0.727
AIC15133.1
Hypothetical protein; No homology to any previously reported sequences.
  
 0.724
AIC16734.1
RPA-like protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; cell process.
  
 0.721
rpoA
DNA-directed RNA polymerase subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
 
 
 0.703
rpoD
DNA-directed RNA polymerase, subunit D; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
   
 
 0.684
Your Current Organism:
Nitrososphaera viennensis
NCBI taxonomy Id: 926571
Other names: Candidatus Nitrososphaera sp. EN76, N. viennensis EN76, Nitrososphaera viennensis EN76, Nitrososphaera viennensis str. EN76, Nitrososphaera viennensis strain EN76
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.