STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
grpEMolecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] (191 aa)    
Predicted Functional Partners:
dnaK
Chaperone protein dnaK; Acts as a chaperone.
 
 
 0.999
dnaJ-2
Chaperone protein DnaJ; Function of strongly homologous gene; factor.
 
 
 0.973
dnaJ-1
Putative chaperone protein DnaJ; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor.
 
 
 0.900
AIC16124.1
Putative chaperone DnaJ; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor.
 
 
 0.895
AIC15714.1
Putative chaperonin Hsp60/Cpn60/TCP-1; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; factor; Belongs to the TCP-1 chaperonin family.
  
 0.750
ths1
Archaeal thermosome subunit; Function of strongly homologous gene; factor; Belongs to the TCP-1 chaperonin family.
  
 0.750
ths2
Archaeal thermosome subunit; Function of strongly homologous gene; factor; Belongs to the TCP-1 chaperonin family.
  
 0.750
ths3
Archaeal thermosome; Function of strongly homologous gene; factor; Belongs to the TCP-1 chaperonin family.
  
 0.750
ths4
Archaeal thermosome; Function of strongly homologous gene; factor; Belongs to the TCP-1 chaperonin family.
  
 0.750
ths5
Archaeal thermosome; Function of strongly homologous gene; factor; Belongs to the TCP-1 chaperonin family.
  
 0.750
Your Current Organism:
Nitrososphaera viennensis
NCBI taxonomy Id: 926571
Other names: Candidatus Nitrososphaera sp. EN76, N. viennensis EN76, Nitrososphaera viennensis EN76, Nitrososphaera viennensis str. EN76, Nitrososphaera viennensis strain EN76
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.