THI4 protein (Steccherinum ochraceum) - STRING interaction network

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THI4

Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...] (321 aa)

Predicted Functional Partners:

EIP91_008714

0.908

ADO1

0.687

RIB7

0.677

EIP91_011117

0.668

EIP91_010026

0.553

EIP91_002285

0.487

EIP91_012180

0.451

PDC1

0.432

TEF1

0.431

TUF1

0.428

Your Current Organism:

Steccherinum ochraceum

NCBI taxonomy Id: 92696
Other names: S. ochraceum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADO1	EIP91_008714	A0A4R0RIJ8	A0A4R0R4R4	Adenosine kinase.	Uncharacterized protein.	0.699
ADO1	RIB7	A0A4R0RIJ8	A0A4R0RHL6	Adenosine kinase.	2,5-diamino-6-(Ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase.	0.470
ADO1	THI4	A0A4R0RIJ8	A0A4R0RK43	Adenosine kinase.	Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...]	0.687
EIP91_002285	EIP91_008714	A0A4R0RKV8	A0A4R0R4R4	Nudix hydrolase domain-containing protein.	Uncharacterized protein.	0.826
EIP91_002285	THI4	A0A4R0RKV8	A0A4R0RK43	Nudix hydrolase domain-containing protein.	Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...]	0.487
EIP91_008714	ADO1	A0A4R0R4R4	A0A4R0RIJ8	Uncharacterized protein.	Adenosine kinase.	0.699
EIP91_008714	EIP91_002285	A0A4R0R4R4	A0A4R0RKV8	Uncharacterized protein.	Nudix hydrolase domain-containing protein.	0.826
EIP91_008714	EIP91_010026	A0A4R0R4R4	A0A4R0RA94	Uncharacterized protein.	Lactamase_B domain-containing protein.	0.904
EIP91_008714	EIP91_011117	A0A4R0R4R4	A0A4R0RTS2	Uncharacterized protein.	PfkB domain-containing protein.	0.699
EIP91_008714	RIB7	A0A4R0R4R4	A0A4R0RHL6	Uncharacterized protein.	2,5-diamino-6-(Ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase.	0.699
EIP91_008714	THI4	A0A4R0R4R4	A0A4R0RK43	Uncharacterized protein.	Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...]	0.908
EIP91_010026	EIP91_008714	A0A4R0RA94	A0A4R0R4R4	Lactamase_B domain-containing protein.	Uncharacterized protein.	0.904
EIP91_010026	THI4	A0A4R0RA94	A0A4R0RK43	Lactamase_B domain-containing protein.	Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...]	0.553
EIP91_011117	EIP91_008714	A0A4R0RTS2	A0A4R0R4R4	PfkB domain-containing protein.	Uncharacterized protein.	0.699
EIP91_011117	THI4	A0A4R0RTS2	A0A4R0RK43	PfkB domain-containing protein.	Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...]	0.668
EIP91_012180	THI4	A0A4R0RNK3	A0A4R0RK43	Uncharacterized protein.	Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...]	0.451
PDC1	THI4	A0A4R0R672	A0A4R0RK43	Pyruvate decarboxylase 1.	Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...]	0.432
RIB7	ADO1	A0A4R0RHL6	A0A4R0RIJ8	2,5-diamino-6-(Ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase.	Adenosine kinase.	0.470
RIB7	EIP91_008714	A0A4R0RHL6	A0A4R0R4R4	2,5-diamino-6-(Ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase.	Uncharacterized protein.	0.699
RIB7	THI4	A0A4R0RHL6	A0A4R0RK43	2,5-diamino-6-(Ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase.	Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...]	0.677

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