AKF03682.1 protein (Sandaracinus amylolyticus)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

AKF03682.1

Putative serine/threonine phosphatase. (325 aa)

Predicted Functional Partners:

polA

0.909

polA-2

0.909

AKF03681.1

0.774

AKF09165.1

0.744

AKF03680.1

0.718

AKF05859.1

0.698

AKF08261.1

0.698

AKF08695.1

0.698

AKF08850.1

0.698

AKF08331.1

0.695

Your Current Organism:

Sandaracinus amylolyticus

NCBI taxonomy Id: 927083
Other names: DSM 53668, NCCB 100362, S. amylolyticus, Sandaracinus amylolyticus Mohr et al. 2012, Sorangiineae bacterium NOSO 4, strain NOSO-4

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKF03680.1	AKF03681.1	DB32_000829	DB32_000830	Putative oxidoreductase.	4-hydroxybenzoyl-CoA thioesterase family active site protein.	0.723
AKF03680.1	AKF03682.1	DB32_000829	DB32_000831	Putative oxidoreductase.	Putative serine/threonine phosphatase.	0.718
AKF03681.1	AKF03680.1	DB32_000830	DB32_000829	4-hydroxybenzoyl-CoA thioesterase family active site protein.	Putative oxidoreductase.	0.723
AKF03681.1	AKF03682.1	DB32_000830	DB32_000831	4-hydroxybenzoyl-CoA thioesterase family active site protein.	Putative serine/threonine phosphatase.	0.774
AKF03682.1	AKF03680.1	DB32_000831	DB32_000829	Putative serine/threonine phosphatase.	Putative oxidoreductase.	0.718
AKF03682.1	AKF03681.1	DB32_000831	DB32_000830	Putative serine/threonine phosphatase.	4-hydroxybenzoyl-CoA thioesterase family active site protein.	0.774
AKF03682.1	AKF05859.1	DB32_000831	DB32_003008	Putative serine/threonine phosphatase.	Exonuclease SbcC.	0.698
AKF03682.1	AKF08261.1	DB32_000831	DB32_005410	Putative serine/threonine phosphatase.	Exonuclease SbcC.	0.698
AKF03682.1	AKF08331.1	DB32_000831	DB32_005480	Putative serine/threonine phosphatase.	ATP-dependent DNA helicase RecQ.	0.695
AKF03682.1	AKF08695.1	DB32_000831	DB32_005844	Putative serine/threonine phosphatase.	TPR domain protein, putative component of TonB system.	0.698
AKF03682.1	AKF08850.1	DB32_000831	DB32_005999	Putative serine/threonine phosphatase.	Methyltransferase type 11.	0.698
AKF03682.1	AKF09165.1	DB32_000831	DB32_006314	Putative serine/threonine phosphatase.	Serine/threonine protein kinase.	0.744
AKF03682.1	polA	DB32_000831	DB32_002497	Putative serine/threonine phosphatase.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.909
AKF03682.1	polA-2	DB32_000831	DB32_003877	Putative serine/threonine phosphatase.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.909
AKF05859.1	AKF03682.1	DB32_003008	DB32_000831	Exonuclease SbcC.	Putative serine/threonine phosphatase.	0.698
AKF05859.1	AKF08331.1	DB32_003008	DB32_005480	Exonuclease SbcC.	ATP-dependent DNA helicase RecQ.	0.567
AKF05859.1	polA	DB32_003008	DB32_002497	Exonuclease SbcC.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.861
AKF05859.1	polA-2	DB32_003008	DB32_003877	Exonuclease SbcC.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.861
AKF08261.1	AKF03682.1	DB32_005410	DB32_000831	Exonuclease SbcC.	Putative serine/threonine phosphatase.	0.698
AKF08261.1	AKF08331.1	DB32_005410	DB32_005480	Exonuclease SbcC.	ATP-dependent DNA helicase RecQ.	0.567

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.804

expected number of edges:

21

PPI enrichment p-value:

0.291

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051568

Histone H3-K4 methylation

6 of 11

2.61

5.33

4.55e-11

GO:0031497

Chromatin assembly

5 of 69

1.73

2.2

6.49e-06

GO:0006325

Chromatin organization

7 of 185

1.45

2.06

3.55e-07

GO:0051276

Chromosome organization

8 of 310

1.28

1.73

2.94e-07

GO:0034728

Nucleosome organization

3 of 29

1.89

1.37

0.0018

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030527

Structural constituent of chromatin

3 of 13

2.24

1.51

0.0014

GO:0046983

Protein dimerization activity

4 of 62

1.68

1.33

0.0014

GO:0046982

Protein heterodimerization activity

3 of 33

1.83

1.18

0.0045

GO:0042800

Histone methyltransferase activity (H3-K4 specific)

2 of 5

2.47

1.11

0.0093

GO:0042393

Histone binding

3 of 46

1.69

1.0

0.0093

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0048188

Set1C/COMPASS complex

6 of 8

2.75

6.05

2.65e-12

GO:0000786

Nucleosome

3 of 15

2.17

1.97

0.00015

GO:0017053

Transcription repressor complex

2 of 5

2.47

1.41

0.0025

GO:0005694

Chromosome

7 of 331

1.2

1.38

8.77e-06

GO:0032991

Protein-containing complex

11 of 1727

0.68

0.63

7.57e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:230

Mixed, incl. PKMTs methylate histone lysines, and Nucleosome

10 of 61

2.09

6.44

1.90e-17

CL:233

Mixed, incl. Structural constituent of chromatin, and Set1C/COMPASS complex

8 of 37

2.21

6.01

1.65e-14

CL:289

Set1C/COMPASS complex

5 of 5

2.87

5.48

5.39e-11

CL:235

Mixed, incl. Structural constituent of chromatin, and ISWI-type complex

3 of 21

2.03

1.7

0.00043

CL:342

Transcription repressor complex, and Activation of the AP-1 family of transcription factors

2 of 5

2.47

1.32

0.0038

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-4839726

Chromatin organization

6 of 78

1.76

2.62

3.88e-07

MAP-3247509

Chromatin modifying enzymes

6 of 78

1.76

2.62

3.88e-07

MAP-2299718

Condensation of Prophase Chromosomes

3 of 8

2.45

2.16

8.96e-05

MAP-3214858

RMTs methylate histone arginines

3 of 18

2.09

1.73

0.00043

MAP-8951664

Neddylation

4 of 64

1.67

1.57

0.00031

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0035097

Histone methyltransferase complex

5 of 14

2.43

3.97

1.64e-08

GOCC:0048188

Set1C/COMPASS complex

4 of 7

2.63

3.58

1.83e-07

GOCC:0000786

Nucleosome

3 of 16

2.15

1.75

0.00041

GOCC:0032991

Protein-containing complex

9 of 2102

0.5

0.36

0.0137

GOCC:0043229

Intracellular organelle

11 of 3525

0.37

0.29

0.0100

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0158

Chromosome

4 of 17

2.24

2.83

2.45e-06

KW-0544

Nucleosome core

3 of 7

2.5

2.53

1.77e-05

KW-0853

WD repeat

5 of 102

1.56

1.86

1.77e-05

KW-0539

Nucleus

4 of 331

0.95

0.51

0.0425

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001680

WD40 repeat

5 of 112

1.52

1.37

0.00060

IPR015943

WD40/YVTN repeat-like-containing domain superfamily

5 of 146

1.41

1.2

0.0011

IPR035425

CENP-T/Histone H4, histone fold

2 of 4

2.57

1.09

0.0105

IPR001951

Histone H4

2 of 3

2.7

1.09

0.0105

IPR009072

Histone-fold

3 of 31

1.86

1.04

0.0090

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00320

WD40 repeats

5 of 120

1.49

1.57

0.00010

SM00417

Histone H4

2 of 3

2.7

1.42

0.0026

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