araQ_6 protein (Epibacterium multivorans) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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araQ_6

Carbohydrate ABC transporter membrane protein 2, CUT1 family; Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane. (256 aa)

Predicted Functional Partners:

ugpA

0.919

ugpB_3

0.906

ugpC_9

0.899

ycjO_1

0.894

lacF_1

0.894

lacF_3

0.893

lacF_2

0.893

lacF_5

0.892

malK_1

0.890

malK_2

0.872

Your Current Organism:

Epibacterium multivorans

NCBI taxonomy Id: 928856
Other names: CECT 7557, DSM 26470, E. multivorans, KCTC 23350, Tropicibacter multivorans, Tropicibacter multivorans Lucena et al. 2012, Tropicibacter sp. CECT 7557, strain MD5

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
araQ_6	lacF_1	SAMN04488049_102339	SAMN04488049_11334	Carbohydrate ABC transporter membrane protein 2, CUT1 family; Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane.	Carbohydrate ABC transporter membrane protein 1, CUT1 family (TC 3.A.1.1.-).	0.894
araQ_6	lacF_2	SAMN04488049_102339	SAMN04488049_111127	Carbohydrate ABC transporter membrane protein 2, CUT1 family; Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane.	Carbohydrate ABC transporter membrane protein 1, CUT1 family.	0.893
araQ_6	lacF_3	SAMN04488049_102339	SAMN04488049_10770	Carbohydrate ABC transporter membrane protein 2, CUT1 family; Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane.	Raffinose/stachyose/melibiose transport system permease protein.	0.893
araQ_6	lacF_5	SAMN04488049_102339	SAMN04488049_102106	Carbohydrate ABC transporter membrane protein 2, CUT1 family; Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane.	Carbohydrate ABC transporter membrane protein 1, CUT1 family.	0.892
araQ_6	malK_1	SAMN04488049_102339	SAMN04488049_111129	Carbohydrate ABC transporter membrane protein 2, CUT1 family; Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane.	Carbohydrate ABC transporter ATP-binding protein, CUT1 family; Belongs to the ABC transporter superfamily.	0.890
araQ_6	malK_2	SAMN04488049_102339	SAMN04488049_10769	Carbohydrate ABC transporter membrane protein 2, CUT1 family; Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane.	Carbohydrate ABC transporter ATP-binding protein, CUT1 family; Belongs to the ABC transporter superfamily.	0.872
araQ_6	ugpA	SAMN04488049_102339	SAMN04488049_102471	Carbohydrate ABC transporter membrane protein 2, CUT1 family; Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane.	Carbohydrate ABC transporter membrane protein 1, CUT1 family.	0.919
araQ_6	ugpB_3	SAMN04488049_102339	SAMN04488049_102472	Carbohydrate ABC transporter membrane protein 2, CUT1 family; Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane.	Carbohydrate ABC transporter substrate-binding protein, CUT1 family (TC 3.A.1.1.-).	0.906
araQ_6	ugpC_9	SAMN04488049_102339	SAMN04488049_102469	Carbohydrate ABC transporter membrane protein 2, CUT1 family; Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane.	Carbohydrate ABC transporter ATP-binding protein, CUT1 family; Part of the ABC transporter complex UgpABCE involved in sn- glycerol-3-phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. sn-glycerol-3- phosphate importer (TC 3.A.1.1.3) family.	0.899
araQ_6	ycjO_1	SAMN04488049_102339	SAMN04488049_10739	Carbohydrate ABC transporter membrane protein 2, CUT1 family; Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane.	Carbohydrate ABC transporter membrane protein 1, CUT1 family.	0.894
lacF_1	araQ_6	SAMN04488049_11334	SAMN04488049_102339	Carbohydrate ABC transporter membrane protein 1, CUT1 family (TC 3.A.1.1.-).	Carbohydrate ABC transporter membrane protein 2, CUT1 family; Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane.	0.894
lacF_1	malK_1	SAMN04488049_11334	SAMN04488049_111129	Carbohydrate ABC transporter membrane protein 1, CUT1 family (TC 3.A.1.1.-).	Carbohydrate ABC transporter ATP-binding protein, CUT1 family; Belongs to the ABC transporter superfamily.	0.821
lacF_1	malK_2	SAMN04488049_11334	SAMN04488049_10769	Carbohydrate ABC transporter membrane protein 1, CUT1 family (TC 3.A.1.1.-).	Carbohydrate ABC transporter ATP-binding protein, CUT1 family; Belongs to the ABC transporter superfamily.	0.785
lacF_1	ugpB_3	SAMN04488049_11334	SAMN04488049_102472	Carbohydrate ABC transporter membrane protein 1, CUT1 family (TC 3.A.1.1.-).	Carbohydrate ABC transporter substrate-binding protein, CUT1 family (TC 3.A.1.1.-).	0.676
lacF_1	ugpC_9	SAMN04488049_11334	SAMN04488049_102469	Carbohydrate ABC transporter membrane protein 1, CUT1 family (TC 3.A.1.1.-).	Carbohydrate ABC transporter ATP-binding protein, CUT1 family; Part of the ABC transporter complex UgpABCE involved in sn- glycerol-3-phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. sn-glycerol-3- phosphate importer (TC 3.A.1.1.3) family.	0.825
lacF_2	araQ_6	SAMN04488049_111127	SAMN04488049_102339	Carbohydrate ABC transporter membrane protein 1, CUT1 family.	Carbohydrate ABC transporter membrane protein 2, CUT1 family; Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane.	0.893
lacF_2	malK_1	SAMN04488049_111127	SAMN04488049_111129	Carbohydrate ABC transporter membrane protein 1, CUT1 family.	Carbohydrate ABC transporter ATP-binding protein, CUT1 family; Belongs to the ABC transporter superfamily.	0.967
lacF_2	malK_2	SAMN04488049_111127	SAMN04488049_10769	Carbohydrate ABC transporter membrane protein 1, CUT1 family.	Carbohydrate ABC transporter ATP-binding protein, CUT1 family; Belongs to the ABC transporter superfamily.	0.872
lacF_2	ugpA	SAMN04488049_111127	SAMN04488049_102471	Carbohydrate ABC transporter membrane protein 1, CUT1 family.	Carbohydrate ABC transporter membrane protein 1, CUT1 family.	0.658
lacF_2	ugpB_3	SAMN04488049_111127	SAMN04488049_102472	Carbohydrate ABC transporter membrane protein 1, CUT1 family.	Carbohydrate ABC transporter substrate-binding protein, CUT1 family (TC 3.A.1.1.-).	0.620

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Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.949

expected number of edges:

12

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051123

RNA polymerase II preinitiation complex assembly

8 of 18

2.92

9.32

1.35e-18

GO:0006367

Transcription initiation from RNA polymerase II promoter

9 of 34

2.7

9.28

2.13e-19

GO:0006352

DNA-templated transcription, initiation

10 of 81

2.36

8.24

2.13e-19

GO:0042789

mRNA transcription by RNA polymerase II

8 of 41

2.56

7.65

2.33e-16

GO:0060261

Positive regulation of transcription initiation from RNA polymerase II promoter

8 of 46

2.51

7.42

4.48e-16

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016251

RNA polymerase II general transcription initiation factor activity

5 of 25

2.57

4.39

3.55e-09

GO:0140296

General transcription initiation factor binding

5 of 54

2.24

3.54

6.18e-08

GO:0017025

TBP-class protein binding

4 of 28

2.43

3.15

8.77e-07

GO:0046982

Protein heterodimerization activity

8 of 334

1.65

2.94

2.81e-09

GO:0008134

Transcription factor binding

8 of 636

1.37

1.99

8.87e-08

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005669

Transcription factor TFIID complex

10 of 29

2.81

11.72

3.14e-24

GO:0033276

Transcription factor TFTC complex

6 of 14

2.9

7.14

3.19e-14

GO:0070461

SAGA-type complex

7 of 37

2.55

6.95

8.57e-15

GO:0000124

SAGA complex

4 of 23

2.51

3.73

6.89e-08

GO:0071339

MLL1 complex

4 of 34

2.34

3.35

2.61e-07

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4168

RNA polymerase II preinitiation complex assembly

9 of 10

3.23

12.24

1.25e-23

CL:4125

Transcription factor TFIID complex, and Transcription factor TFIIH holo complex

10 of 34

2.74

11.2

1.63e-23

CL:4172

SLIK (SAGA-like) complex, and Lateral mesoderm formation

5 of 5

3.27

6.35

2.44e-12

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ccan03022

Basal transcription factors

9 of 34

2.7

9.97

5.56e-21

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-76042

RNA Polymerase II Transcription Initiation And Promoter Clearance

9 of 49

2.54

8.68

5.40e-19

MAP-75953

RNA Polymerase II Transcription Initiation

9 of 49

2.54

8.68

5.40e-19

MAP-73779

RNA Polymerase II Transcription Pre-Initiation And Promoter Opening

9 of 49

2.54

8.68

5.40e-19

MAP-73776

RNA Polymerase II Promoter Escape

9 of 49

2.54

8.68

5.40e-19

MAP-674695

RNA Polymerase II Pre-transcription Events

9 of 101

2.22

6.9

4.69e-17

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016591

RNA polymerase II, holoenzyme

10 of 64

2.47

9.27

4.03e-21

GOCC:0070461

SAGA-type complex

7 of 34

2.59

7.03

7.63e-15

GOCC:0071339

MLL1 complex

4 of 26

2.46

3.55

1.37e-07

GOCC:0005654

Nucleoplasm

11 of 696

1.47

3.04

1.99e-14

GOCC:1990234

Transferase complex

11 of 858

1.38

2.6

1.71e-13

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0396

Initiation factor

4 of 59

2.1

2.46

1.07e-05

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