STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mcl2(3S)-malyl-CoA thioesterase; Belongs to the HpcH/HpaI aldolase family. (284 aa)    
Predicted Functional Partners:
SFC58216.1
L-erythro-3-methylmalyl-CoA dehydratase.
 
 
 0.969
lcfB_6
Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II.
 
      0.898
mdh_2
Malate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
 
 0.830
tme
Malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+).
 
 
 0.823
maeB
Malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+).
  
 
 0.799
bbsF_2
Crotonobetainyl-CoA:carnitine CoA-transferase CaiB; Belongs to the CoA-transferase III family.
 
 
 0.779
glcB
Malate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily.
    
 0.778
sucC
succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
    
 0.772
frc_3
CoA:oxalate CoA-transferase; Belongs to the CoA-transferase III family.
 
 
 0.768
sucD
succinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 
 0.761
Your Current Organism:
Epibacterium multivorans
NCBI taxonomy Id: 928856
Other names: CECT 7557, DSM 26470, E. multivorans, KCTC 23350, Tropicibacter multivorans, Tropicibacter multivorans Lucena et al. 2012, Tropicibacter sp. CECT 7557, strain MD5
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