AFK03538.1 protein (Emticicia oligotrophica)

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

AFK03538.1

KEGG: sli:Slin_4386 hypothetical protein; SPTR: Putative uncharacterized protein. (141 aa)

Predicted Functional Partners:

AFK03537.1

0.494

AFK03591.1

0.479

AFK03533.1

0.438

AFK04353.1

0.418

AFK04925.1

0.410

Your Current Organism:

Emticicia oligotrophica

NCBI taxonomy Id: 929562
Other names: E. oligotrophica DSM 17448, Emticicia oligotrophica DSM 17448, Emticicia oligotrophica GPTSA100-15, Emticicia oligotrophica str. DSM 17448, Emticicia oligotrophica strain DSM 17448

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFK03533.1	AFK03538.1	Emtol_2397	Emtol_2402	PDZ/DHR/GLGF domain protein; PFAM: PDZ domain (Also known as DHR or GLGF); InterPro IPR001478; KEGG: dfe:Dfer_3870 PDZ/DHR/GLGF domain protein; PFAM: PDZ/DHR/GLGF; SMART: PDZ/DHR/GLGF; SPTR: PDZ/DHR/GLGF domain protein.	KEGG: sli:Slin_4386 hypothetical protein; SPTR: Putative uncharacterized protein.	0.438
AFK03537.1	AFK03538.1	Emtol_2401	Emtol_2402	PFAM: Protein of unknown function (DUF2807); KEGG: dfe:Dfer_4258 hypothetical protein; SPTR: Putative uncharacterized protein.	KEGG: sli:Slin_4386 hypothetical protein; SPTR: Putative uncharacterized protein.	0.494
AFK03538.1	AFK03533.1	Emtol_2402	Emtol_2397	KEGG: sli:Slin_4386 hypothetical protein; SPTR: Putative uncharacterized protein.	PDZ/DHR/GLGF domain protein; PFAM: PDZ domain (Also known as DHR or GLGF); InterPro IPR001478; KEGG: dfe:Dfer_3870 PDZ/DHR/GLGF domain protein; PFAM: PDZ/DHR/GLGF; SMART: PDZ/DHR/GLGF; SPTR: PDZ/DHR/GLGF domain protein.	0.438
AFK03538.1	AFK03537.1	Emtol_2402	Emtol_2401	KEGG: sli:Slin_4386 hypothetical protein; SPTR: Putative uncharacterized protein.	PFAM: Protein of unknown function (DUF2807); KEGG: dfe:Dfer_4258 hypothetical protein; SPTR: Putative uncharacterized protein.	0.494
AFK03538.1	AFK03591.1	Emtol_2402	Emtol_2455	KEGG: sli:Slin_4386 hypothetical protein; SPTR: Putative uncharacterized protein.	KEGG: sli:Slin_5605 hypothetical protein; SPTR: Putative uncharacterized protein.	0.479
AFK03538.1	AFK04353.1	Emtol_2402	Emtol_3224	KEGG: sli:Slin_4386 hypothetical protein; SPTR: Putative uncharacterized protein.	PFAM: Peptidase family M23; InterPro IPR016047; KEGG: sli:Slin_3597 peptidase M23; PFAM: Peptidase M23; SPTR: Peptidase M23.	0.418
AFK03538.1	AFK04925.1	Emtol_2402	Emtol_3799	KEGG: sli:Slin_4386 hypothetical protein; SPTR: Putative uncharacterized protein.	PFAM: Insertion element protein; COGs: COG3677 Transposase and inactivated derivatives; KEGG: sli:Slin_2050 insertion element protein; SPTR: Insertion element protein.	0.410
AFK03591.1	AFK03538.1	Emtol_2455	Emtol_2402	KEGG: sli:Slin_5605 hypothetical protein; SPTR: Putative uncharacterized protein.	KEGG: sli:Slin_4386 hypothetical protein; SPTR: Putative uncharacterized protein.	0.479
AFK04353.1	AFK03538.1	Emtol_3224	Emtol_2402	PFAM: Peptidase family M23; InterPro IPR016047; KEGG: sli:Slin_3597 peptidase M23; PFAM: Peptidase M23; SPTR: Peptidase M23.	KEGG: sli:Slin_4386 hypothetical protein; SPTR: Putative uncharacterized protein.	0.418
AFK04925.1	AFK03538.1	Emtol_3799	Emtol_2402	PFAM: Insertion element protein; COGs: COG3677 Transposase and inactivated derivatives; KEGG: sli:Slin_2050 insertion element protein; SPTR: Insertion element protein.	KEGG: sli:Slin_4386 hypothetical protein; SPTR: Putative uncharacterized protein.	0.410

Network Stats

number of nodes:

7

number of edges:

8

average node degree:

2.29

avg. local clustering coefficient:

0.829

expected number of edges:

6

PPI enrichment p-value:

0.293

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032446

Protein modification by small protein conjugation

9 of 195

1.86

4.35

8.06e-13

GO:0016567

Protein ubiquitination

8 of 176

1.85

4.05

1.13e-11

GO:0019941

Modification-dependent protein catabolic process

9 of 249

1.75

3.85

2.88e-12

GO:0006511

Ubiquitin-dependent protein catabolic process

8 of 241

1.71

3.42

9.55e-11

GO:0036211

Protein modification process

11 of 932

1.26

2.08

7.05e-12

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031625

Ubiquitin protein ligase binding

4 of 31

2.3

2.63

8.04e-06

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031461

cullin-RING ubiquitin ligase complex

5 of 54

2.16

3.29

1.56e-07

GO:0031463

Cul3-RING ubiquitin ligase complex

3 of 3

3.19

3.28

1.11e-06

GO:0019005

SCF ubiquitin ligase complex

3 of 22

2.33

2.11

9.49e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2915

Protein neddylation, and SCF ubiquitin ligase complex

8 of 24

2.72

8.54

1.14e-17

CL:2914

cullin-RING ubiquitin ligase complex, and COP9 signalosome

9 of 42

2.52

8.51

1.16e-18

CL:2918

Protein neddylation, and SCF ubiquitin ligase complex

7 of 19

2.76

7.62

1.53e-15

CL:2920

Mixed, incl. Nuclear SCF ubiquitin ligase complex, and Cullin

4 of 10

2.79

3.99

3.72e-08

CL:2923

Nuclear SCF ubiquitin ligase complex, and SKP1 component, POZ domain

2 of 5

2.79

1.41

0.0027

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04120

Ubiquitin mediated proteolysis

8 of 131

1.98

4.85

3.81e-13

map04111

Cell cycle - yeast

5 of 156

1.7

2.29

2.34e-06

map04141

Protein processing in endoplasmic reticulum

5 of 221

1.55

1.92

8.49e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-983168

Antigen processing: Ubiquitination & Proteasome degradation

6 of 148

1.8

2.77

2.04e-07

MAP-983169

Class I MHC mediated antigen processing & presentation

6 of 217

1.63

2.3

9.54e-07

MAP-1280218

Adaptive Immune System

6 of 301

1.49

1.91

4.32e-06

MAP-9020702

Interleukin-1 signaling

2 of 14

2.35

1.12

0.0086

MAP-446652

Interleukin-1 family signaling

2 of 14

2.35

1.12

0.0086

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031461

cullin-RING ubiquitin ligase complex

6 of 65

2.16

4.06

1.88e-09

GOCC:0031463

Cul3-RING ubiquitin ligase complex

3 of 3

3.19

3.31

9.96e-07

GOCC:0017117

Single-stranded DNA-dependent ATP-dependent DNA helicase complex

3 of 3

3.19

3.31

9.96e-07

GOCC:0043291

RAVE complex

3 of 5

2.97

3.14

1.86e-06

GOCC:0019005

SCF ubiquitin ligase complex

3 of 37

2.1

1.86

0.00022

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045093

Cullin

3 of 4

3.07

2.57

2.20e-05

IPR001373

Cullin, N-terminal

3 of 5

2.97

2.56

2.20e-05

IPR016159

Cullin repeat-like-containing domain superfamily

3 of 6

2.89

2.55

2.20e-05

IPR019559

Cullin protein, neddylation domain

2 of 3

3.02

1.4

0.0030

IPR036317

Cullin homology domain superfamily

2 of 4

2.89

1.35

0.0036

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00884

Cullin protein neddylation domain

2 of 3

3.02

1.6

0.0013

SM00182

Cullin

2 of 3

3.02

1.6

0.0013

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