STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
trpD2Anthranilate phosphoribosyltransferase 2. (342 aa)    
Predicted Functional Partners:
pabB
Aminodeoxychorismate synthase component 1.
 
 
 0.978
trpE
Anthranilate synthase component 1; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]
 
 
 0.972
trpC
Indole-3-glycerol phosphate synthase; Belongs to the TrpC family.
 
  
 0.924
trpA
Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
 
  
 0.907
trpB
Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
 
  
 0.905
trpF
N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family.
 
  
 0.897
trpG
Anthranilate synthase component 2.
 
  
 0.885
narB
Nitrate reductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
 
     0.851
hisI
Phosphoribosyl-AMP cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family.
  
  
 0.619
hisC
Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
  
  
 0.596
Your Current Organism:
Acidithiobacillus thiooxidans
NCBI taxonomy Id: 930
Other names: A. thiooxidans, ATCC 19377, CIP 104597, DSM 14887, JCM 3867, NCIMB 8343, Thiobacillus concretivorus, Thiobacillus crenatus, Thiobacillus lobatus, Thiobacillus thermitanus, Thiobacillus thiooxidans, Thiobacillus umbonatus, Thiobacterium thiooxydans
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