STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hprKHPr kinase/phosphorylase; Belongs to the HPrK/P family. (310 aa)    
Predicted Functional Partners:
crh
HPr-like protein Crh.
 
 
 
 0.935
fruA
PTS system fructose-specific EIIABC component.
 
  
 0.906
ptsI_1
Phosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
 
   
 0.901
levD
PTS system fructose-specific EIIA component.
 
   
 0.890
rapZ
RNase adapter protein RapZ; Displays ATPase and GTPase activities.
     
 0.822
ptsI_2
Phosphoenolpyruvate-protein phosphotransferase; Belongs to the PEP-utilizing enzyme family.
 
 
 
 0.805
yvyD
Ribosome hibernation promotion factor.
     
 0.794
lgt
Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family.
  
  
 0.666
pgl
6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
  
  
 0.661
uvrB_2
UvrABC system protein B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and [...]
    
 0.644
Your Current Organism:
Acidithiobacillus thiooxidans
NCBI taxonomy Id: 930
Other names: A. thiooxidans, ATCC 19377, CIP 104597, DSM 14887, JCM 3867, NCIMB 8343, Thiobacillus concretivorus, Thiobacillus crenatus, Thiobacillus lobatus, Thiobacillus thermitanus, Thiobacillus thiooxidans, Thiobacillus umbonatus, Thiobacterium thiooxydans
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