NANS protein (Sarcophilus harrisii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

NANS

N-acetylneuraminate synthase. (316 aa)

Predicted Functional Partners:

CMAS

0.995

GNE

0.955

LOC100929712

0.903

NPL

0.855

HOGA1

0.855

G3WS30_SARHA

0.754

ST3GAL5

0.746

SNX8

0.660

GLUD1

0.647

ASS1

0.643

Your Current Organism:

Sarcophilus harrisii

NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASS1	GLUD1	ENSSHAP00000017854	ENSSHAP00000010935	Argininosuccinate synthase 1.	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.536
ASS1	NANS	ENSSHAP00000017854	ENSSHAP00000002011	Argininosuccinate synthase 1.	N-acetylneuraminate synthase.	0.643
CMAS	HOGA1	ENSSHAP00000016324	ENSSHAP00000021316	Cytidine monophosphate N-acetylneuraminic acid synthetase.	4-hydroxy-2-oxoglutarate aldolase 1; Belongs to the DapA family.	0.882
CMAS	LOC100929712	ENSSHAP00000016324	ENSSHAP00000002179	Cytidine monophosphate N-acetylneuraminic acid synthetase.	Rieske domain-containing protein.	0.912
CMAS	NANS	ENSSHAP00000016324	ENSSHAP00000002011	Cytidine monophosphate N-acetylneuraminic acid synthetase.	N-acetylneuraminate synthase.	0.995
CMAS	NPL	ENSSHAP00000016324	ENSSHAP00000009284	Cytidine monophosphate N-acetylneuraminic acid synthetase.	N-acetylneuraminate pyruvate lyase; Belongs to the DapA family.	0.882
G3WS30_SARHA	NANS	ENSSHAP00000018235	ENSSHAP00000002011	Uncharacterized protein; Belongs to the glycosyltransferase 29 family.	N-acetylneuraminate synthase.	0.754
GLUD1	ASS1	ENSSHAP00000010935	ENSSHAP00000017854	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	Argininosuccinate synthase 1.	0.536
GLUD1	NANS	ENSSHAP00000010935	ENSSHAP00000002011	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	N-acetylneuraminate synthase.	0.647
GNE	HOGA1	ENSSHAP00000009292	ENSSHAP00000021316	Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase.	4-hydroxy-2-oxoglutarate aldolase 1; Belongs to the DapA family.	0.846
GNE	NANS	ENSSHAP00000009292	ENSSHAP00000002011	Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase.	N-acetylneuraminate synthase.	0.955
GNE	NPL	ENSSHAP00000009292	ENSSHAP00000009284	Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase.	N-acetylneuraminate pyruvate lyase; Belongs to the DapA family.	0.846
HOGA1	CMAS	ENSSHAP00000021316	ENSSHAP00000016324	4-hydroxy-2-oxoglutarate aldolase 1; Belongs to the DapA family.	Cytidine monophosphate N-acetylneuraminic acid synthetase.	0.882
HOGA1	GNE	ENSSHAP00000021316	ENSSHAP00000009292	4-hydroxy-2-oxoglutarate aldolase 1; Belongs to the DapA family.	Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase.	0.846
HOGA1	LOC100929712	ENSSHAP00000021316	ENSSHAP00000002179	4-hydroxy-2-oxoglutarate aldolase 1; Belongs to the DapA family.	Rieske domain-containing protein.	0.845
HOGA1	NANS	ENSSHAP00000021316	ENSSHAP00000002011	4-hydroxy-2-oxoglutarate aldolase 1; Belongs to the DapA family.	N-acetylneuraminate synthase.	0.855
HOGA1	SNX8	ENSSHAP00000021316	ENSSHAP00000020020	4-hydroxy-2-oxoglutarate aldolase 1; Belongs to the DapA family.	Sorting nexin 8.	0.429
LOC100929712	CMAS	ENSSHAP00000002179	ENSSHAP00000016324	Rieske domain-containing protein.	Cytidine monophosphate N-acetylneuraminic acid synthetase.	0.912
LOC100929712	HOGA1	ENSSHAP00000002179	ENSSHAP00000021316	Rieske domain-containing protein.	4-hydroxy-2-oxoglutarate aldolase 1; Belongs to the DapA family.	0.845
LOC100929712	NANS	ENSSHAP00000002179	ENSSHAP00000002011	Rieske domain-containing protein.	N-acetylneuraminate synthase.	0.903