Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
G3VK97_SARHADUF5598 domain-containing protein. (113 aa)    
Predicted Functional Partners:
G3VAR6_SARHA
NAPRTase domain-containing protein.
 
     0.950
NMNAT1
Nicotinamide-nucleotide adenylyltransferase.
   
 
 0.849
SIRT1
Sirtuin 1.
     
 0.846
NMNAT3
Nicotinamide-nucleotide adenylyltransferase.
   
 
 0.820
NMNAT2
Nicotinamide nucleotide adenylyltransferase 2.
   
 
 0.819
NMRK1
Nicotinamide riboside kinase 1.
   
 
 0.806
SIRT3
NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.
     
 0.802
SIRT4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...]
   
 
 0.783
SIRT6
Sirtuin 6.
     
 0.783
G3VAB4_SARHA
Deacetylase sirtuin-type domain-containing protein.
     
 0.780
Your Current Organism:
Sarcophilus harrisii
NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil
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