LTA protein (Sarcophilus harrisii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

LTA

Lymphotoxin alpha; Belongs to the tumor necrosis factor family. (201 aa)

Predicted Functional Partners:

LTB

0.997

LTBR

0.990

TNFRSF1B

0.983

G3WMH3_SARHA

0.974

TNF

0.906

CD4

0.771

TNFRSF25

0.652

PLEKHG5

0.652

PLEKHG6

0.652

CD40LG

0.598

Your Current Organism:

Sarcophilus harrisii

NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD4	CD40LG	ENSSHAP00000018659	ENSSHAP00000009115	Uncharacterized protein.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.741
CD4	LTA	ENSSHAP00000018659	ENSSHAP00000004470	Uncharacterized protein.	Lymphotoxin alpha; Belongs to the tumor necrosis factor family.	0.771
CD4	LTB	ENSSHAP00000018659	ENSSHAP00000004721	Uncharacterized protein.	Lymphotoxin beta; Belongs to the tumor necrosis factor family.	0.477
CD4	LTBR	ENSSHAP00000018659	ENSSHAP00000017050	Uncharacterized protein.	Lymphotoxin beta receptor.	0.537
CD40LG	CD4	ENSSHAP00000009115	ENSSHAP00000018659	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Uncharacterized protein.	0.741
CD40LG	G3WMH3_SARHA	ENSSHAP00000009115	ENSSHAP00000016628	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Uncharacterized protein.	0.481
CD40LG	LTA	ENSSHAP00000009115	ENSSHAP00000004470	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Lymphotoxin alpha; Belongs to the tumor necrosis factor family.	0.598
CD40LG	LTB	ENSSHAP00000009115	ENSSHAP00000004721	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Lymphotoxin beta; Belongs to the tumor necrosis factor family.	0.506
CD40LG	LTBR	ENSSHAP00000009115	ENSSHAP00000017050	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Lymphotoxin beta receptor.	0.749
CD40LG	TNF	ENSSHAP00000009115	ENSSHAP00000004546	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.496
CD40LG	TNFRSF1B	ENSSHAP00000009115	ENSSHAP00000010609	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Uncharacterized protein.	0.559
G3WMH3_SARHA	CD40LG	ENSSHAP00000016628	ENSSHAP00000009115	Uncharacterized protein.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.481
G3WMH3_SARHA	LTA	ENSSHAP00000016628	ENSSHAP00000004470	Uncharacterized protein.	Lymphotoxin alpha; Belongs to the tumor necrosis factor family.	0.974
G3WMH3_SARHA	LTBR	ENSSHAP00000016628	ENSSHAP00000017050	Uncharacterized protein.	Lymphotoxin beta receptor.	0.686
G3WMH3_SARHA	TNF	ENSSHAP00000016628	ENSSHAP00000004546	Uncharacterized protein.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.529
G3WMH3_SARHA	TNFRSF1B	ENSSHAP00000016628	ENSSHAP00000010609	Uncharacterized protein.	Uncharacterized protein.	0.703
LTA	CD4	ENSSHAP00000004470	ENSSHAP00000018659	Lymphotoxin alpha; Belongs to the tumor necrosis factor family.	Uncharacterized protein.	0.771
LTA	CD40LG	ENSSHAP00000004470	ENSSHAP00000009115	Lymphotoxin alpha; Belongs to the tumor necrosis factor family.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.598
LTA	G3WMH3_SARHA	ENSSHAP00000004470	ENSSHAP00000016628	Lymphotoxin alpha; Belongs to the tumor necrosis factor family.	Uncharacterized protein.	0.974
LTA	LTB	ENSSHAP00000004470	ENSSHAP00000004721	Lymphotoxin alpha; Belongs to the tumor necrosis factor family.	Lymphotoxin beta; Belongs to the tumor necrosis factor family.	0.997