LGR4 protein (Sarcophilus harrisii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Sarcophilus harrisii

NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FZD6	G3VIP7_SARHA	ENSSHAP00000005062	ENSSHAP00000003051	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family.	RING-type domain-containing protein.	0.921
FZD6	LGR4	ENSSHAP00000005062	ENSSHAP00000015374	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family.	Leucine rich repeat containing G protein-coupled receptor 4.	0.814
FZD6	LRP6	ENSSHAP00000005062	ENSSHAP00000016432	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.940
FZD6	RNF43	ENSSHAP00000005062	ENSSHAP00000012426	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family.	RING-type domain-containing protein.	0.910
G3VIP7_SARHA	FZD6	ENSSHAP00000003051	ENSSHAP00000005062	RING-type domain-containing protein.	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family.	0.921
G3VIP7_SARHA	LGR4	ENSSHAP00000003051	ENSSHAP00000015374	RING-type domain-containing protein.	Leucine rich repeat containing G protein-coupled receptor 4.	0.988
G3VIP7_SARHA	LGR6	ENSSHAP00000003051	ENSSHAP00000014763	RING-type domain-containing protein.	Leucine rich repeat containing G protein-coupled receptor 6.	0.511
G3VIP7_SARHA	LRP6	ENSSHAP00000003051	ENSSHAP00000016432	RING-type domain-containing protein.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.860
G3VIP7_SARHA	RNF43	ENSSHAP00000003051	ENSSHAP00000012426	RING-type domain-containing protein.	RING-type domain-containing protein.	0.752
G3VIP7_SARHA	RSPO1	ENSSHAP00000003051	ENSSHAP00000014699	RING-type domain-containing protein.	R-spondin 1.	0.993
G3VIP7_SARHA	RSPO2	ENSSHAP00000003051	ENSSHAP00000013048	RING-type domain-containing protein.	R-spondin 2.	0.995
G3VIP7_SARHA	RSPO3	ENSSHAP00000003051	ENSSHAP00000021838	RING-type domain-containing protein.	R-spondin 3.	0.986
G3VIP7_SARHA	RSPO4	ENSSHAP00000003051	ENSSHAP00000012798	RING-type domain-containing protein.	R-spondin 4.	0.949
LGR4	FZD6	ENSSHAP00000015374	ENSSHAP00000005062	Leucine rich repeat containing G protein-coupled receptor 4.	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family.	0.814
LGR4	G3VIP7_SARHA	ENSSHAP00000015374	ENSSHAP00000003051	Leucine rich repeat containing G protein-coupled receptor 4.	RING-type domain-containing protein.	0.988
LGR4	LGR6	ENSSHAP00000015374	ENSSHAP00000014763	Leucine rich repeat containing G protein-coupled receptor 4.	Leucine rich repeat containing G protein-coupled receptor 6.	0.883
LGR4	LRP6	ENSSHAP00000015374	ENSSHAP00000016432	Leucine rich repeat containing G protein-coupled receptor 4.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.949
LGR4	NDP	ENSSHAP00000015374	ENSSHAP00000013817	Leucine rich repeat containing G protein-coupled receptor 4.	Norrin cystine knot growth factor NDP.	0.820
LGR4	RNF43	ENSSHAP00000015374	ENSSHAP00000012426	Leucine rich repeat containing G protein-coupled receptor 4.	RING-type domain-containing protein.	0.923
LGR4	RSPO1	ENSSHAP00000015374	ENSSHAP00000014699	Leucine rich repeat containing G protein-coupled receptor 4.	R-spondin 1.	0.995