| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALPL | BGLAP | ENSSHAP00000020643 | ENSSHAP00000016568 | Alkaline phosphatase. | Osteocalcin; Binds strongly to apatite and calcium. | 0.729 |
| ALPL | IBSP | ENSSHAP00000020643 | ENSSHAP00000005242 | Alkaline phosphatase. | Integrin binding sialoprotein. | 0.584 |
| ALPL | SPP1 | ENSSHAP00000020643 | ENSSHAP00000001626 | Alkaline phosphatase. | Secreted phosphoprotein 1. | 0.591 |
| ALPL | TNFRSF11B | ENSSHAP00000020643 | ENSSHAP00000018745 | Alkaline phosphatase. | Tumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. | 0.417 |
| BGLAP | ALPL | ENSSHAP00000016568 | ENSSHAP00000020643 | Osteocalcin; Binds strongly to apatite and calcium. | Alkaline phosphatase. | 0.729 |
| BGLAP | IBSP | ENSSHAP00000016568 | ENSSHAP00000005242 | Osteocalcin; Binds strongly to apatite and calcium. | Integrin binding sialoprotein. | 0.769 |
| BGLAP | PTH | ENSSHAP00000016568 | ENSSHAP00000020713 | Osteocalcin; Binds strongly to apatite and calcium. | Uncharacterized protein. | 0.733 |
| BGLAP | RUNX1 | ENSSHAP00000016568 | ENSSHAP00000017397 | Osteocalcin; Binds strongly to apatite and calcium. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.653 |
| BGLAP | RUNX2 | ENSSHAP00000016568 | ENSSHAP00000011580 | Osteocalcin; Binds strongly to apatite and calcium. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.653 |
| BGLAP | RUNX3 | ENSSHAP00000016568 | ENSSHAP00000014712 | Osteocalcin; Binds strongly to apatite and calcium. | RUNX family transcription factor 3. | 0.653 |
| BGLAP | SPARC | ENSSHAP00000016568 | ENSSHAP00000008424 | Osteocalcin; Binds strongly to apatite and calcium. | Secreted protein acidic and cysteine rich. | 0.649 |
| BGLAP | SPP1 | ENSSHAP00000016568 | ENSSHAP00000001626 | Osteocalcin; Binds strongly to apatite and calcium. | Secreted phosphoprotein 1. | 0.751 |
| BGLAP | TNFRSF11B | ENSSHAP00000016568 | ENSSHAP00000018745 | Osteocalcin; Binds strongly to apatite and calcium. | Tumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. | 0.663 |
| BGLAP | TNFSF11 | ENSSHAP00000016568 | ENSSHAP00000001456 | Osteocalcin; Binds strongly to apatite and calcium. | TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. | 0.695 |
| IBSP | ALPL | ENSSHAP00000005242 | ENSSHAP00000020643 | Integrin binding sialoprotein. | Alkaline phosphatase. | 0.584 |
| IBSP | BGLAP | ENSSHAP00000005242 | ENSSHAP00000016568 | Integrin binding sialoprotein. | Osteocalcin; Binds strongly to apatite and calcium. | 0.769 |
| IBSP | SPARC | ENSSHAP00000005242 | ENSSHAP00000008424 | Integrin binding sialoprotein. | Secreted protein acidic and cysteine rich. | 0.539 |
| IBSP | SPP1 | ENSSHAP00000005242 | ENSSHAP00000001626 | Integrin binding sialoprotein. | Secreted phosphoprotein 1. | 0.801 |
| IBSP | TNFRSF11B | ENSSHAP00000005242 | ENSSHAP00000018745 | Integrin binding sialoprotein. | Tumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. | 0.452 |
| IBSP | TNFSF11 | ENSSHAP00000005242 | ENSSHAP00000001456 | Integrin binding sialoprotein. | TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. | 0.447 |
