Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
EU95_01715-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1188 aa)    
Predicted Functional Partners:
EU95_1844
5,10-methylenetetrahydrofolate reductase; Alternative locus ID: PMIT9201_0176; Belongs to the methylenetetrahydrofolate reductase family.
  
 
 0.997
EU95_1610
Glycine dehydrogenase (decarboxylating) (glycine cleavage system P protein); Alternative locus ID: PMIT9201_1041; Belongs to the GcvP family.
  
 
 0.975
EU95_1528
Homoserine dehydrogenase; Alternative locus ID: PMIT9201_1531.
  
 
 0.974
EU95_1287
O-acetylhomoserine sulfhydrylase; Alternative locus ID: PMIT9201_1397; O-succinylhomoserine sulfhydrylase.
  
 
 0.970
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
  
 
 0.970
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
    
 0.969
EU95_0051
Cystathionine beta-lyase; Alternative locus ID: PMIT9201_1693.
  
 
 0.968
EU95_0052
Cystathionine gamma-synthase; Alternative locus ID: PMIT9201_1694.
  
 
 0.968
ilvE
Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
    
 0.960
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
    
 0.958
Your Current Organism:
Prochlorococcus marinus MIT9201
NCBI taxonomy Id: 93057
Other names: P. marinus str. MIT 9201, Prochlorococcus marinus str. MIT 9201, Prochlorococcus sp. MIT 9201, Prochlorococcus sp. MIT9201
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