| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EU95_0171 | EU95_0501 | EU95_0171 | EU95_0501 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Alternative locus ID: PMIT9201_0466; Dihydrolipoamide dehydrogenase. | 0.838 |
| EU95_0171 | EU95_0876 | EU95_0171 | EU95_0876 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Ferredoxin-dependent glutamate synthase; Alternative locus ID: PMIT9201_0699. | 0.500 |
| EU95_0171 | EU95_1590 | EU95_0171 | EU95_1590 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Aminomethyltransferase (glycine cleavage system T protein); Alternative locus ID: PMIT9201_1021. | 0.946 |
| EU95_0171 | EU95_1610 | EU95_0171 | EU95_1610 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine dehydrogenase (decarboxylating) (glycine cleavage system P protein); Alternative locus ID: PMIT9201_1041; Belongs to the GcvP family. | 0.975 |
| EU95_0171 | EU95_1844 | EU95_0171 | EU95_1844 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 5,10-methylenetetrahydrofolate reductase; Alternative locus ID: PMIT9201_0176; Belongs to the methylenetetrahydrofolate reductase family. | 0.997 |
| EU95_0171 | folD | EU95_0171 | EU95_1510 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.944 |
| EU95_0171 | gcvH | EU95_0171 | EU95_1609 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.916 |
| EU95_0171 | glyA | EU95_0171 | EU95_1735 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.951 |
| EU95_0215 | EU95_0501 | EU95_0215 | EU95_0501 | Glutamine synthetase type I; Alternative locus ID: PMIT9201_0890. | Alternative locus ID: PMIT9201_0466; Dihydrolipoamide dehydrogenase. | 0.903 |
| EU95_0215 | EU95_0876 | EU95_0215 | EU95_0876 | Glutamine synthetase type I; Alternative locus ID: PMIT9201_0890. | Ferredoxin-dependent glutamate synthase; Alternative locus ID: PMIT9201_0699. | 0.981 |
| EU95_0215 | EU95_1590 | EU95_0215 | EU95_1590 | Glutamine synthetase type I; Alternative locus ID: PMIT9201_0890. | Aminomethyltransferase (glycine cleavage system T protein); Alternative locus ID: PMIT9201_1021. | 0.903 |
| EU95_0215 | EU95_1610 | EU95_0215 | EU95_1610 | Glutamine synthetase type I; Alternative locus ID: PMIT9201_0890. | Glycine dehydrogenase (decarboxylating) (glycine cleavage system P protein); Alternative locus ID: PMIT9201_1041; Belongs to the GcvP family. | 0.929 |
| EU95_0215 | gcvH | EU95_0215 | EU95_1609 | Glutamine synthetase type I; Alternative locus ID: PMIT9201_0890. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.903 |
| EU95_0215 | glyA | EU95_0215 | EU95_1735 | Glutamine synthetase type I; Alternative locus ID: PMIT9201_0890. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.578 |
| EU95_0501 | EU95_0171 | EU95_0501 | EU95_0171 | Alternative locus ID: PMIT9201_0466; Dihydrolipoamide dehydrogenase. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.838 |
| EU95_0501 | EU95_0215 | EU95_0501 | EU95_0215 | Alternative locus ID: PMIT9201_0466; Dihydrolipoamide dehydrogenase. | Glutamine synthetase type I; Alternative locus ID: PMIT9201_0890. | 0.903 |
| EU95_0501 | EU95_0876 | EU95_0501 | EU95_0876 | Alternative locus ID: PMIT9201_0466; Dihydrolipoamide dehydrogenase. | Ferredoxin-dependent glutamate synthase; Alternative locus ID: PMIT9201_0699. | 0.952 |
| EU95_0501 | EU95_1590 | EU95_0501 | EU95_1590 | Alternative locus ID: PMIT9201_0466; Dihydrolipoamide dehydrogenase. | Aminomethyltransferase (glycine cleavage system T protein); Alternative locus ID: PMIT9201_1021. | 0.974 |
| EU95_0501 | EU95_1610 | EU95_0501 | EU95_1610 | Alternative locus ID: PMIT9201_0466; Dihydrolipoamide dehydrogenase. | Glycine dehydrogenase (decarboxylating) (glycine cleavage system P protein); Alternative locus ID: PMIT9201_1041; Belongs to the GcvP family. | 0.970 |
| EU95_0501 | EU95_1844 | EU95_0501 | EU95_1844 | Alternative locus ID: PMIT9201_0466; Dihydrolipoamide dehydrogenase. | 5,10-methylenetetrahydrofolate reductase; Alternative locus ID: PMIT9201_0176; Belongs to the methylenetetrahydrofolate reductase family. | 0.902 |
