| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EU95_0171 | EU95_0876 | EU95_0171 | EU95_0876 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Ferredoxin-dependent glutamate synthase; Alternative locus ID: PMIT9201_0699. | 0.500 |
| EU95_0171 | EU95_1376 | EU95_0171 | EU95_1376 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphoglycerate mutase; Alternative locus ID: PMIT9201_1267; Belongs to the phosphoglycerate mutase family. | 0.424 |
| EU95_0171 | EU95_1590 | EU95_0171 | EU95_1590 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Aminomethyltransferase (glycine cleavage system T protein); Alternative locus ID: PMIT9201_1021. | 0.946 |
| EU95_0171 | EU95_1610 | EU95_0171 | EU95_1610 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine dehydrogenase (decarboxylating) (glycine cleavage system P protein); Alternative locus ID: PMIT9201_1041; Belongs to the GcvP family. | 0.975 |
| EU95_0171 | EU95_1844 | EU95_0171 | EU95_1844 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 5,10-methylenetetrahydrofolate reductase; Alternative locus ID: PMIT9201_0176; Belongs to the methylenetetrahydrofolate reductase family. | 0.997 |
| EU95_0171 | folD | EU95_0171 | EU95_1510 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.944 |
| EU95_0171 | gcvH | EU95_0171 | EU95_1609 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.916 |
| EU95_0171 | glyA | EU95_0171 | EU95_1735 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.951 |
| EU95_0171 | purH | EU95_0171 | EU95_1728 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | IMP cyclohydrolase; Alternative locus ID: PMIT9201_0060; Phosphoribosylaminoimidazolecarboxamide formyltransferase. | 0.898 |
| EU95_0171 | purN | EU95_0171 | EU95_0185 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.895 |
| EU95_0876 | EU95_0171 | EU95_0876 | EU95_0171 | Ferredoxin-dependent glutamate synthase; Alternative locus ID: PMIT9201_0699. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.500 |
| EU95_0876 | EU95_1376 | EU95_0876 | EU95_1376 | Ferredoxin-dependent glutamate synthase; Alternative locus ID: PMIT9201_0699. | Phosphoglycerate mutase; Alternative locus ID: PMIT9201_1267; Belongs to the phosphoglycerate mutase family. | 0.553 |
| EU95_0876 | EU95_1590 | EU95_0876 | EU95_1590 | Ferredoxin-dependent glutamate synthase; Alternative locus ID: PMIT9201_0699. | Aminomethyltransferase (glycine cleavage system T protein); Alternative locus ID: PMIT9201_1021. | 0.925 |
| EU95_0876 | EU95_1610 | EU95_0876 | EU95_1610 | Ferredoxin-dependent glutamate synthase; Alternative locus ID: PMIT9201_0699. | Glycine dehydrogenase (decarboxylating) (glycine cleavage system P protein); Alternative locus ID: PMIT9201_1041; Belongs to the GcvP family. | 0.958 |
| EU95_0876 | EU95_1844 | EU95_0876 | EU95_1844 | Ferredoxin-dependent glutamate synthase; Alternative locus ID: PMIT9201_0699. | 5,10-methylenetetrahydrofolate reductase; Alternative locus ID: PMIT9201_0176; Belongs to the methylenetetrahydrofolate reductase family. | 0.696 |
| EU95_0876 | folD | EU95_0876 | EU95_1510 | Ferredoxin-dependent glutamate synthase; Alternative locus ID: PMIT9201_0699. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.620 |
| EU95_0876 | gcvH | EU95_0876 | EU95_1609 | Ferredoxin-dependent glutamate synthase; Alternative locus ID: PMIT9201_0699. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.952 |
| EU95_0876 | glyA | EU95_0876 | EU95_1735 | Ferredoxin-dependent glutamate synthase; Alternative locus ID: PMIT9201_0699. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.955 |
| EU95_0876 | purH | EU95_0876 | EU95_1728 | Ferredoxin-dependent glutamate synthase; Alternative locus ID: PMIT9201_0699. | IMP cyclohydrolase; Alternative locus ID: PMIT9201_0060; Phosphoribosylaminoimidazolecarboxamide formyltransferase. | 0.972 |
| EU95_1376 | EU95_0171 | EU95_1376 | EU95_0171 | Phosphoglycerate mutase; Alternative locus ID: PMIT9201_1267; Belongs to the phosphoglycerate mutase family. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.424 |
