| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EU95_0171 | EU95_0442 | EU95_0171 | EU95_0442 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | D-3-phosphoglycerate dehydrogenase; Alternative locus ID: PMIT9201_0407; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.570 |
| EU95_0171 | EU95_0760 | EU95_0171 | EU95_0760 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Aldehyde dehydrogenase; Alternative locus ID: PMIT9201_1639; Belongs to the aldehyde dehydrogenase family. | 0.849 |
| EU95_0171 | EU95_1376 | EU95_0171 | EU95_1376 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphoglycerate mutase; Alternative locus ID: PMIT9201_1267; Belongs to the phosphoglycerate mutase family. | 0.424 |
| EU95_0171 | EU95_1610 | EU95_0171 | EU95_1610 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine dehydrogenase (decarboxylating) (glycine cleavage system P protein); Alternative locus ID: PMIT9201_1041; Belongs to the GcvP family. | 0.975 |
| EU95_0171 | EU95_1977 | EU95_0171 | EU95_1977 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine--glyoxylate aminotransferase; Alternative locus ID: PMIT9201_0309. | 0.772 |
| EU95_0171 | glyA | EU95_0171 | EU95_1735 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.951 |
| EU95_0206 | EU95_0442 | EU95_0206 | EU95_0442 | Pyruvate kinase; Alternative locus ID: PMIT9201_0881; Belongs to the pyruvate kinase family. | D-3-phosphoglycerate dehydrogenase; Alternative locus ID: PMIT9201_0407; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.898 |
| EU95_0206 | EU95_0760 | EU95_0206 | EU95_0760 | Pyruvate kinase; Alternative locus ID: PMIT9201_0881; Belongs to the pyruvate kinase family. | Aldehyde dehydrogenase; Alternative locus ID: PMIT9201_1639; Belongs to the aldehyde dehydrogenase family. | 0.942 |
| EU95_0206 | EU95_1376 | EU95_0206 | EU95_1376 | Pyruvate kinase; Alternative locus ID: PMIT9201_0881; Belongs to the pyruvate kinase family. | Phosphoglycerate mutase; Alternative locus ID: PMIT9201_1267; Belongs to the phosphoglycerate mutase family. | 0.568 |
| EU95_0206 | EU95_1610 | EU95_0206 | EU95_1610 | Pyruvate kinase; Alternative locus ID: PMIT9201_0881; Belongs to the pyruvate kinase family. | Glycine dehydrogenase (decarboxylating) (glycine cleavage system P protein); Alternative locus ID: PMIT9201_1041; Belongs to the GcvP family. | 0.490 |
| EU95_0206 | EU95_1977 | EU95_0206 | EU95_1977 | Pyruvate kinase; Alternative locus ID: PMIT9201_0881; Belongs to the pyruvate kinase family. | Serine--glyoxylate aminotransferase; Alternative locus ID: PMIT9201_0309. | 0.658 |
| EU95_0206 | fumC | EU95_0206 | EU95_0922 | Pyruvate kinase; Alternative locus ID: PMIT9201_0881; Belongs to the pyruvate kinase family. | Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.606 |
| EU95_0206 | glyA | EU95_0206 | EU95_1735 | Pyruvate kinase; Alternative locus ID: PMIT9201_0881; Belongs to the pyruvate kinase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.663 |
| EU95_0442 | EU95_0171 | EU95_0442 | EU95_0171 | D-3-phosphoglycerate dehydrogenase; Alternative locus ID: PMIT9201_0407; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.570 |
| EU95_0442 | EU95_0206 | EU95_0442 | EU95_0206 | D-3-phosphoglycerate dehydrogenase; Alternative locus ID: PMIT9201_0407; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Pyruvate kinase; Alternative locus ID: PMIT9201_0881; Belongs to the pyruvate kinase family. | 0.898 |
| EU95_0442 | EU95_0760 | EU95_0442 | EU95_0760 | D-3-phosphoglycerate dehydrogenase; Alternative locus ID: PMIT9201_0407; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Aldehyde dehydrogenase; Alternative locus ID: PMIT9201_1639; Belongs to the aldehyde dehydrogenase family. | 0.663 |
| EU95_0442 | EU95_1376 | EU95_0442 | EU95_1376 | D-3-phosphoglycerate dehydrogenase; Alternative locus ID: PMIT9201_0407; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Phosphoglycerate mutase; Alternative locus ID: PMIT9201_1267; Belongs to the phosphoglycerate mutase family. | 0.517 |
| EU95_0442 | EU95_1610 | EU95_0442 | EU95_1610 | D-3-phosphoglycerate dehydrogenase; Alternative locus ID: PMIT9201_0407; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Glycine dehydrogenase (decarboxylating) (glycine cleavage system P protein); Alternative locus ID: PMIT9201_1041; Belongs to the GcvP family. | 0.878 |
| EU95_0442 | EU95_1977 | EU95_0442 | EU95_1977 | D-3-phosphoglycerate dehydrogenase; Alternative locus ID: PMIT9201_0407; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Serine--glyoxylate aminotransferase; Alternative locus ID: PMIT9201_0309. | 0.933 |
| EU95_0442 | EU95_1984 | EU95_0442 | EU95_1984 | D-3-phosphoglycerate dehydrogenase; Alternative locus ID: PMIT9201_0407; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 4-hydroxythreonine-4-phosphate dehydrogenase; Alternative locus ID: PMIT9201_0316; Belongs to the PdxA family. | 0.459 |