STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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[Homology]
Score
ABD29264.1Conserved hypothetical protein; Belongs to the HpcH/HpaI aldolase family. (258 aa)    
Predicted Functional Partners:
sbnD
Conserved hypothetical protein; Involved in staphyloferrin B secretion. Belongs to the major facilitator superfamily.
 
  
 0.898
sbnB
Ornithine cyclodeaminase, putative; Catalyzes the hydrolysis of N-((2S)-2-amino-2-carboxyethyl)- L-glutamate (ACEGA) to form L-2,3-diaminopropionic acid and 2- oxoglutarate. Involved in the biosynthesis of L-2,3-diaminopropionic acid (L-Dap), a precursor of staphyloferrin B and antibiotics. Belongs to the ornithine cyclodeaminase/mu-crystallin family.
 
  
 0.894
sbnC
Conserved hypothetical protein; Catalyzes the condensation of L-2,3-diaminopropionyl-citryl- diaminoethane and 2-oxoglutarate to form staphyloferrin B, the fourth and last step in staphyloferrin B biosynthesis.
 
  
 0.893
sbnH
Conserved hypothetical protein; Catalyzes the decarboxylation of citryl-L-2,3- diaminopropionic acid to citryl-diaminoethane, the second step in staphyloferrin B biosynthesis; Belongs to the Orn/Lys/Arg decarboxylase class-II family.
 
   
 0.885
sbnI
Conserved hypothetical protein; Free serine kinase that uses ATP to phosphorylate L-serine to yield O-phospho-L-serine and ADP. O-phospho-L-serine serves as a substrate for SbnA and is a precursor for staphyloferrin B biosynthesis. Is also a DNA-binding regulatory protein that senses heme to control gene expression for siderophore biosynthesis. Binds to DNA within the sbnC coding region and is required for expression of genes in the sbn operon from sbnD onward.
  
  
 0.876
sbnE
Conserved hypothetical protein; Catalyzes the synthesis of citryl-L-2,3-diaminopropionic acid from L-2,3-diaminopropionic acid (L-Dap) and citrate, the first step in staphyloferrin B biosynthesis.
  
  
 0.859
sbnF
Conserved hypothetical protein; Catalyzes the condensation of L-2,3-diaminopropionic acid (L- Dap) and citryl-diaminoethane to form L-2,3-diaminopropionyl-citryl- diaminoethane, the third step in staphyloferrin B biosynthesis.
  
  
 0.859
sbnA
Conserved hypothetical protein; Catalyzes the synthesis of N-((2S)-2-amino-2-carboxyethyl)-L- glutamate (ACEGA) from O-phospho-L-serine and L-glutamate. Involved in the biosynthesis of L-2,3-diaminopropionic acid (L-Dap), a precursor of staphyloferrin B and antibiotics.
  
  
 0.845
menC
Conserved hypothetical protein; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
  
 
 0.468
ABD31911.1
Conserved hypothetical protein.
  
     0.448
Your Current Organism:
Staphylococcus aureus
NCBI taxonomy Id: 93061
Other names: S. aureus subsp. aureus NCTC 8325, Staphylococcus aureus NCTC 8325, Staphylococcus aureus subsp. aureus NCTC 8325, Staphylococcus aureus subsp. aureus str. NCTC 8325, Staphylococcus aureus subsp. aureus strain NCTC 8325
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