Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ABD29434.1Conserved hypothetical protein. (93 aa)    
Predicted Functional Partners:
essB
Conserved hypothetical protein; Component of the type VII secretion system (Ess) (Probable). Required for the secretion of EsxA and EsxB (By similarity).
  
 
 0.956
essC
Conserved hypothetical protein; Component of the type VII secretion system (Ess). Required for the secretion of substrates including EsxA and EsxB. However, unable to support secretion of the substrate protein EsxC. Belongs to the EssC family.
  
   0.890
esaA
Conserved hypothetical protein; Component of the type VII secretion system (Ess). Provides together with EssB and other components such as EssC and EssE a secretion platform across the cytoplasmic membrane in the host.
  
  
 0.868
ABD29433.1
Conserved hypothetical protein.
       0.856
esxA
Conserved hypothetical protein; Virulence factor that is important for the establishment of infection in the host. EsxA is required for EsxB synthesis as well as secretion (By similarity). Modulates host cell apoptotic pathways and mediates together with EsxB the release of S.aureus from the host cell. By acting on apoptosis, plays a role in the modulation of dendritic cell-mediated immunity (By similarity).
     
 0.648
ABD29437.1
Conserved hypothetical protein.
       0.597
essD
Conserved hypothetical protein; Component of the type VII secretion system (Ess). Plays a role in Ess secretion during infection. Required for the efficient secretion of EsxA. Required for abscess formation and staphylococcal persistence in host tissues (By similarity). Possesses a toxic DNase activity that is modulated by EssG by forming a nuclease toxin- antitoxin pair. This nuclease toxin targets competitor bacteria.
  
    0.581
esxB
Conserved hypothetical protein; Virulence factor that is important for the establishment of infection in the host. EsxB is required for EsxA synthesis as well as secretion (By similarity). Mediates together with EsxA the release of S.aureus from the host cell. Inhibits also host cytokine production and thus modulates dendritic cell-mediated immunity (By similarity).
       0.567
essE
Conserved hypothetical protein; Component of the type VII secretion system (Ess). Plays a role in Esx protein secretion. Plays an essential role in the processing and secretion of EssD.
       0.567
ABD29440.1
Conserved hypothetical protein.
       0.567
Your Current Organism:
Staphylococcus aureus
NCBI taxonomy Id: 93061
Other names: S. aureus subsp. aureus NCTC 8325, Staphylococcus aureus NCTC 8325, Staphylococcus aureus subsp. aureus NCTC 8325, Staphylococcus aureus subsp. aureus str. NCTC 8325, Staphylococcus aureus subsp. aureus strain NCTC 8325
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