STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ABD29437.1Conserved hypothetical protein. (130 aa)    
Predicted Functional Partners:
ABD29434.1
Conserved hypothetical protein.
     
 0.837
esxB
Conserved hypothetical protein; Virulence factor that is important for the establishment of infection in the host. EsxB is required for EsxA synthesis as well as secretion (By similarity). Mediates together with EsxA the release of S.aureus from the host cell. Inhibits also host cytokine production and thus modulates dendritic cell-mediated immunity (By similarity).
     
 0.802
essE
Conserved hypothetical protein; Component of the type VII secretion system (Ess). Plays a role in Esx protein secretion. Plays an essential role in the processing and secretion of EssD.
       0.732
ABD29440.1
Conserved hypothetical protein.
       0.732
essD
Conserved hypothetical protein; Component of the type VII secretion system (Ess). Plays a role in Ess secretion during infection. Required for the efficient secretion of EsxA. Required for abscess formation and staphylococcal persistence in host tissues (By similarity). Possesses a toxic DNase activity that is modulated by EssG by forming a nuclease toxin- antitoxin pair. This nuclease toxin targets competitor bacteria.
       0.721
essG
Conserved hypothetical protein; Component of the type VII secretion system (Ess). Acts also as part of toxin-antitoxin system. Counteracts the toxic effect of EssD via direct interaction.
       0.706
essC
Conserved hypothetical protein; Component of the type VII secretion system (Ess). Required for the secretion of substrates including EsxA and EsxB. However, unable to support secretion of the substrate protein EsxC. Belongs to the EssC family.
       0.675
essB
Conserved hypothetical protein; Component of the type VII secretion system (Ess) (Probable). Required for the secretion of EsxA and EsxB (By similarity).
       0.617
esaA
Conserved hypothetical protein; Component of the type VII secretion system (Ess). Provides together with EssB and other components such as EssC and EssE a secretion platform across the cytoplasmic membrane in the host.
       0.597
ABD29433.1
Conserved hypothetical protein.
       0.597
Your Current Organism:
Staphylococcus aureus
NCBI taxonomy Id: 93061
Other names: S. aureus subsp. aureus NCTC 8325, Staphylococcus aureus NCTC 8325, Staphylococcus aureus subsp. aureus NCTC 8325, Staphylococcus aureus subsp. aureus str. NCTC 8325, Staphylococcus aureus subsp. aureus strain NCTC 8325
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.