node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABD29214.1 | ABD30221.1 | SAOUHSC_00025 | SAOUHSC_01107 | Conserved hypothetical protein. | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.886 |
ABD29214.1 | guaA | SAOUHSC_00025 | SAOUHSC_00375 | Conserved hypothetical protein. | GMP synthase, putative; Catalyzes the synthesis of GMP from XMP. | 0.899 |
ABD29214.1 | guaB | SAOUHSC_00025 | SAOUHSC_00374 | Conserved hypothetical protein. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.889 |
ABD29214.1 | purA | SAOUHSC_00025 | SAOUHSC_00019 | Conserved hypothetical protein. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.888 |
ABD29214.1 | purB | SAOUHSC_00025 | SAOUHSC_02126 | Conserved hypothetical protein. | Adenylosuccinate lyase. | 0.888 |
ABD29214.1 | purH | SAOUHSC_00025 | SAOUHSC_01017 | Conserved hypothetical protein. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.887 |
ABD29594.1 | ABD29638.1 | SAOUHSC_00435 | SAOUHSC_00485 | Glutamate synthase, large subunit, putative. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.552 |
ABD29594.1 | ABD30221.1 | SAOUHSC_00435 | SAOUHSC_01107 | Glutamate synthase, large subunit, putative. | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.421 |
ABD29594.1 | guaA | SAOUHSC_00435 | SAOUHSC_00375 | Glutamate synthase, large subunit, putative. | GMP synthase, putative; Catalyzes the synthesis of GMP from XMP. | 0.902 |
ABD29594.1 | guaB | SAOUHSC_00435 | SAOUHSC_00374 | Glutamate synthase, large subunit, putative. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.829 |
ABD29594.1 | guaC | SAOUHSC_00435 | SAOUHSC_01330 | Glutamate synthase, large subunit, putative. | Guanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.534 |
ABD29594.1 | purA | SAOUHSC_00435 | SAOUHSC_00019 | Glutamate synthase, large subunit, putative. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.426 |
ABD29594.1 | purB | SAOUHSC_00435 | SAOUHSC_02126 | Glutamate synthase, large subunit, putative. | Adenylosuccinate lyase. | 0.541 |
ABD29594.1 | purH | SAOUHSC_00435 | SAOUHSC_01017 | Glutamate synthase, large subunit, putative. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.913 |
ABD29638.1 | ABD29594.1 | SAOUHSC_00485 | SAOUHSC_00435 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Glutamate synthase, large subunit, putative. | 0.552 |
ABD29638.1 | ABD30221.1 | SAOUHSC_00485 | SAOUHSC_01107 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.888 |
ABD29638.1 | guaA | SAOUHSC_00485 | SAOUHSC_00375 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | GMP synthase, putative; Catalyzes the synthesis of GMP from XMP. | 0.947 |
ABD29638.1 | guaB | SAOUHSC_00485 | SAOUHSC_00374 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.932 |
ABD29638.1 | guaC | SAOUHSC_00485 | SAOUHSC_01330 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Guanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.901 |
ABD29638.1 | purA | SAOUHSC_00485 | SAOUHSC_00019 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.943 |