| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| chp | flr | SAOUHSC_02169 | SAOUHSC_01112 | Conserved hypothetical phage protein; Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leucyl-phenylalanine (fMLP). Acts by binding directly to the C5a receptor (C5aR) and formylated peptide receptor (FPR), thereby blocking the C5a- and fMLP-induced calcium responses (By similarity). Prevents phagocytosis of the bacterium; Belongs to the CHIPS/FLIPr family. | Conserved hypothetical protein; May be involved in countering the first line of host defense mechanisms. Impairs the leukocyte response to FPRL1 agonists by binding directly to host FPRL1 (By similarity); Belongs to the CHIPS/FLIPr family. | 0.618 |
| chp | ssl5 | SAOUHSC_02169 | SAOUHSC_00390 | Conserved hypothetical phage protein; Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leucyl-phenylalanine (fMLP). Acts by binding directly to the C5a receptor (C5aR) and formylated peptide receptor (FPR), thereby blocking the C5a- and fMLP-induced calcium responses (By similarity). Prevents phagocytosis of the bacterium; Belongs to the CHIPS/FLIPr family. | Conserved hypothetical protein; Secreted protein that plays a role in the inhibition of host innate immune system. Modulates the interaction between host SELPLG and P-selectin thereby preventing initial rolling of neutrophils toward the site of infection. Interferes with leukocyte trafficking by inhibiting host metalloproteinase-9/MMP9 activity. Associates also with two different platelet surface receptors GP1A and GP6 leading to platelet activation and aggregation. Belongs to the staphylococcal/streptococcal toxin family. | 0.540 |
| flr | chp | SAOUHSC_01112 | SAOUHSC_02169 | Conserved hypothetical protein; May be involved in countering the first line of host defense mechanisms. Impairs the leukocyte response to FPRL1 agonists by binding directly to host FPRL1 (By similarity); Belongs to the CHIPS/FLIPr family. | Conserved hypothetical phage protein; Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leucyl-phenylalanine (fMLP). Acts by binding directly to the C5a receptor (C5aR) and formylated peptide receptor (FPR), thereby blocking the C5a- and fMLP-induced calcium responses (By similarity). Prevents phagocytosis of the bacterium; Belongs to the CHIPS/FLIPr family. | 0.618 |
| flr | ssl5 | SAOUHSC_01112 | SAOUHSC_00390 | Conserved hypothetical protein; May be involved in countering the first line of host defense mechanisms. Impairs the leukocyte response to FPRL1 agonists by binding directly to host FPRL1 (By similarity); Belongs to the CHIPS/FLIPr family. | Conserved hypothetical protein; Secreted protein that plays a role in the inhibition of host innate immune system. Modulates the interaction between host SELPLG and P-selectin thereby preventing initial rolling of neutrophils toward the site of infection. Interferes with leukocyte trafficking by inhibiting host metalloproteinase-9/MMP9 activity. Associates also with two different platelet surface receptors GP1A and GP6 leading to platelet activation and aggregation. Belongs to the staphylococcal/streptococcal toxin family. | 0.573 |
| ssl4 | ssl5 | SAOUHSC_00389 | SAOUHSC_00390 | Conserved hypothetical protein; Secreted protein that plays a role in immune innate response inhibition by interfering with host TLR2-mediated pathway. | Conserved hypothetical protein; Secreted protein that plays a role in the inhibition of host innate immune system. Modulates the interaction between host SELPLG and P-selectin thereby preventing initial rolling of neutrophils toward the site of infection. Interferes with leukocyte trafficking by inhibiting host metalloproteinase-9/MMP9 activity. Associates also with two different platelet surface receptors GP1A and GP6 leading to platelet activation and aggregation. Belongs to the staphylococcal/streptococcal toxin family. | 0.484 |
| ssl5 | chp | SAOUHSC_00390 | SAOUHSC_02169 | Conserved hypothetical protein; Secreted protein that plays a role in the inhibition of host innate immune system. Modulates the interaction between host SELPLG and P-selectin thereby preventing initial rolling of neutrophils toward the site of infection. Interferes with leukocyte trafficking by inhibiting host metalloproteinase-9/MMP9 activity. Associates also with two different platelet surface receptors GP1A and GP6 leading to platelet activation and aggregation. Belongs to the staphylococcal/streptococcal toxin family. | Conserved hypothetical phage protein; Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leucyl-phenylalanine (fMLP). Acts by binding directly to the C5a receptor (C5aR) and formylated peptide receptor (FPR), thereby blocking the C5a- and fMLP-induced calcium responses (By similarity). Prevents phagocytosis of the bacterium; Belongs to the CHIPS/FLIPr family. | 0.540 |
| ssl5 | flr | SAOUHSC_00390 | SAOUHSC_01112 | Conserved hypothetical protein; Secreted protein that plays a role in the inhibition of host innate immune system. Modulates the interaction between host SELPLG and P-selectin thereby preventing initial rolling of neutrophils toward the site of infection. Interferes with leukocyte trafficking by inhibiting host metalloproteinase-9/MMP9 activity. Associates also with two different platelet surface receptors GP1A and GP6 leading to platelet activation and aggregation. Belongs to the staphylococcal/streptococcal toxin family. | Conserved hypothetical protein; May be involved in countering the first line of host defense mechanisms. Impairs the leukocyte response to FPRL1 agonists by binding directly to host FPRL1 (By similarity); Belongs to the CHIPS/FLIPr family. | 0.573 |
| ssl5 | ssl4 | SAOUHSC_00390 | SAOUHSC_00389 | Conserved hypothetical protein; Secreted protein that plays a role in the inhibition of host innate immune system. Modulates the interaction between host SELPLG and P-selectin thereby preventing initial rolling of neutrophils toward the site of infection. Interferes with leukocyte trafficking by inhibiting host metalloproteinase-9/MMP9 activity. Associates also with two different platelet surface receptors GP1A and GP6 leading to platelet activation and aggregation. Belongs to the staphylococcal/streptococcal toxin family. | Conserved hypothetical protein; Secreted protein that plays a role in immune innate response inhibition by interfering with host TLR2-mediated pathway. | 0.484 |
