| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABD29556.1 | ssl7 | SAOUHSC_00393 | SAOUHSC_00392 | Conserved hypothetical protein. | Conserved hypothetical protein; Plays a role in the inhibition of host complement-mediated lysis and serum bactericidal activity by interacting with complement component C5. Affects all three pathways of complement activation and inhibits the cleavage of C5 by preventing its binding to C5 convertases. In turn, prevents C5a-mediated neutrophil migration. | 0.401 |
| ABD30228.1 | chp | SAOUHSC_01114 | SAOUHSC_02169 | Fibrinogen-binding protein. | Conserved hypothetical phage protein; Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leucyl-phenylalanine (fMLP). Acts by binding directly to the C5a receptor (C5aR) and formylated peptide receptor (FPR), thereby blocking the C5a- and fMLP-induced calcium responses (By similarity). Prevents phagocytosis of the bacterium; Belongs to the CHIPS/FLIPr family. | 0.500 |
| ABD30228.1 | sbi | SAOUHSC_01114 | SAOUHSC_02706 | Fibrinogen-binding protein. | Immunoglobulin G-binding protein Sbi, putative; Plays a role in the inhibition of both the innate and adaptive immune responses. Possesses two N-terminal domains that bind the Fc region of IgG and two domains that form a tripartite complex with complement factors C3b and CFH. By recruiting CFH and C3b, the secreted form acts as a potent complement inhibitor of the alternative pathway-mediated lysis; Belongs to the immunoglobulin-binding protein Sbi family. | 0.559 |
| ABD30228.1 | scn | SAOUHSC_01114 | SAOUHSC_02167 | Fibrinogen-binding protein. | Conserved hypothetical phage protein; Involved in countering the first line of host defense mechanisms. Efficiently inhibits opsonization, phagocytosis and killing of S.aureus by human neutrophils. Acts by binding and stabilizing human C3 convertases (C4b2a and C3bBb), leading to their inactivation. The convertases are no longer able to cleave complement C3, therefore preventing further C3b deposition on the bacterial surface and phagocytosis of the bacterium. Also prevents C5a-induced neutrophil responses; Belongs to the SCIN family. | 0.582 |
| ABD30228.1 | ssl7 | SAOUHSC_01114 | SAOUHSC_00392 | Fibrinogen-binding protein. | Conserved hypothetical protein; Plays a role in the inhibition of host complement-mediated lysis and serum bactericidal activity by interacting with complement component C5. Affects all three pathways of complement activation and inhibits the cleavage of C5 by preventing its binding to C5 convertases. In turn, prevents C5a-mediated neutrophil migration. | 0.414 |
| chp | ABD30228.1 | SAOUHSC_02169 | SAOUHSC_01114 | Conserved hypothetical phage protein; Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leucyl-phenylalanine (fMLP). Acts by binding directly to the C5a receptor (C5aR) and formylated peptide receptor (FPR), thereby blocking the C5a- and fMLP-induced calcium responses (By similarity). Prevents phagocytosis of the bacterium; Belongs to the CHIPS/FLIPr family. | Fibrinogen-binding protein. | 0.500 |
| chp | flr | SAOUHSC_02169 | SAOUHSC_01112 | Conserved hypothetical phage protein; Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leucyl-phenylalanine (fMLP). Acts by binding directly to the C5a receptor (C5aR) and formylated peptide receptor (FPR), thereby blocking the C5a- and fMLP-induced calcium responses (By similarity). Prevents phagocytosis of the bacterium; Belongs to the CHIPS/FLIPr family. | Conserved hypothetical protein; May be involved in countering the first line of host defense mechanisms. Impairs the leukocyte response to FPRL1 agonists by binding directly to host FPRL1 (By similarity); Belongs to the CHIPS/FLIPr family. | 0.618 |
| chp | sbi | SAOUHSC_02169 | SAOUHSC_02706 | Conserved hypothetical phage protein; Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leucyl-phenylalanine (fMLP). Acts by binding directly to the C5a receptor (C5aR) and formylated peptide receptor (FPR), thereby blocking the C5a- and fMLP-induced calcium responses (By similarity). Prevents phagocytosis of the bacterium; Belongs to the CHIPS/FLIPr family. | Immunoglobulin G-binding protein Sbi, putative; Plays a role in the inhibition of both the innate and adaptive immune responses. Possesses two N-terminal domains that bind the Fc region of IgG and two domains that form a tripartite complex with complement factors C3b and CFH. By recruiting CFH and C3b, the secreted form acts as a potent complement inhibitor of the alternative pathway-mediated lysis; Belongs to the immunoglobulin-binding protein Sbi family. | 0.521 |
| chp | scn | SAOUHSC_02169 | SAOUHSC_02167 | Conserved hypothetical phage protein; Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leucyl-phenylalanine (fMLP). Acts by binding directly to the C5a receptor (C5aR) and formylated peptide receptor (FPR), thereby blocking the C5a- and fMLP-induced calcium responses (By similarity). Prevents phagocytosis of the bacterium; Belongs to the CHIPS/FLIPr family. | Conserved hypothetical phage protein; Involved in countering the first line of host defense mechanisms. Efficiently inhibits opsonization, phagocytosis and killing of S.aureus by human neutrophils. Acts by binding and stabilizing human C3 convertases (C4b2a and C3bBb), leading to their inactivation. The convertases are no longer able to cleave complement C3, therefore preventing further C3b deposition on the bacterial surface and phagocytosis of the bacterium. Also prevents C5a-induced neutrophil responses; Belongs to the SCIN family. | 0.618 |
| chp | ssl7 | SAOUHSC_02169 | SAOUHSC_00392 | Conserved hypothetical phage protein; Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leucyl-phenylalanine (fMLP). Acts by binding directly to the C5a receptor (C5aR) and formylated peptide receptor (FPR), thereby blocking the C5a- and fMLP-induced calcium responses (By similarity). Prevents phagocytosis of the bacterium; Belongs to the CHIPS/FLIPr family. | Conserved hypothetical protein; Plays a role in the inhibition of host complement-mediated lysis and serum bactericidal activity by interacting with complement component C5. Affects all three pathways of complement activation and inhibits the cleavage of C5 by preventing its binding to C5 convertases. In turn, prevents C5a-mediated neutrophil migration. | 0.540 |
| flr | chp | SAOUHSC_01112 | SAOUHSC_02169 | Conserved hypothetical protein; May be involved in countering the first line of host defense mechanisms. Impairs the leukocyte response to FPRL1 agonists by binding directly to host FPRL1 (By similarity); Belongs to the CHIPS/FLIPr family. | Conserved hypothetical phage protein; Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leucyl-phenylalanine (fMLP). Acts by binding directly to the C5a receptor (C5aR) and formylated peptide receptor (FPR), thereby blocking the C5a- and fMLP-induced calcium responses (By similarity). Prevents phagocytosis of the bacterium; Belongs to the CHIPS/FLIPr family. | 0.618 |
| flr | scn | SAOUHSC_01112 | SAOUHSC_02167 | Conserved hypothetical protein; May be involved in countering the first line of host defense mechanisms. Impairs the leukocyte response to FPRL1 agonists by binding directly to host FPRL1 (By similarity); Belongs to the CHIPS/FLIPr family. | Conserved hypothetical phage protein; Involved in countering the first line of host defense mechanisms. Efficiently inhibits opsonization, phagocytosis and killing of S.aureus by human neutrophils. Acts by binding and stabilizing human C3 convertases (C4b2a and C3bBb), leading to their inactivation. The convertases are no longer able to cleave complement C3, therefore preventing further C3b deposition on the bacterial surface and phagocytosis of the bacterium. Also prevents C5a-induced neutrophil responses; Belongs to the SCIN family. | 0.498 |
| flr | ssl7 | SAOUHSC_01112 | SAOUHSC_00392 | Conserved hypothetical protein; May be involved in countering the first line of host defense mechanisms. Impairs the leukocyte response to FPRL1 agonists by binding directly to host FPRL1 (By similarity); Belongs to the CHIPS/FLIPr family. | Conserved hypothetical protein; Plays a role in the inhibition of host complement-mediated lysis and serum bactericidal activity by interacting with complement component C5. Affects all three pathways of complement activation and inhibits the cleavage of C5 by preventing its binding to C5 convertases. In turn, prevents C5a-mediated neutrophil migration. | 0.463 |
| sbi | ABD30228.1 | SAOUHSC_02706 | SAOUHSC_01114 | Immunoglobulin G-binding protein Sbi, putative; Plays a role in the inhibition of both the innate and adaptive immune responses. Possesses two N-terminal domains that bind the Fc region of IgG and two domains that form a tripartite complex with complement factors C3b and CFH. By recruiting CFH and C3b, the secreted form acts as a potent complement inhibitor of the alternative pathway-mediated lysis; Belongs to the immunoglobulin-binding protein Sbi family. | Fibrinogen-binding protein. | 0.559 |
| sbi | chp | SAOUHSC_02706 | SAOUHSC_02169 | Immunoglobulin G-binding protein Sbi, putative; Plays a role in the inhibition of both the innate and adaptive immune responses. Possesses two N-terminal domains that bind the Fc region of IgG and two domains that form a tripartite complex with complement factors C3b and CFH. By recruiting CFH and C3b, the secreted form acts as a potent complement inhibitor of the alternative pathway-mediated lysis; Belongs to the immunoglobulin-binding protein Sbi family. | Conserved hypothetical phage protein; Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leucyl-phenylalanine (fMLP). Acts by binding directly to the C5a receptor (C5aR) and formylated peptide receptor (FPR), thereby blocking the C5a- and fMLP-induced calcium responses (By similarity). Prevents phagocytosis of the bacterium; Belongs to the CHIPS/FLIPr family. | 0.521 |
| sbi | scn | SAOUHSC_02706 | SAOUHSC_02167 | Immunoglobulin G-binding protein Sbi, putative; Plays a role in the inhibition of both the innate and adaptive immune responses. Possesses two N-terminal domains that bind the Fc region of IgG and two domains that form a tripartite complex with complement factors C3b and CFH. By recruiting CFH and C3b, the secreted form acts as a potent complement inhibitor of the alternative pathway-mediated lysis; Belongs to the immunoglobulin-binding protein Sbi family. | Conserved hypothetical phage protein; Involved in countering the first line of host defense mechanisms. Efficiently inhibits opsonization, phagocytosis and killing of S.aureus by human neutrophils. Acts by binding and stabilizing human C3 convertases (C4b2a and C3bBb), leading to their inactivation. The convertases are no longer able to cleave complement C3, therefore preventing further C3b deposition on the bacterial surface and phagocytosis of the bacterium. Also prevents C5a-induced neutrophil responses; Belongs to the SCIN family. | 0.582 |
| sbi | ssl7 | SAOUHSC_02706 | SAOUHSC_00392 | Immunoglobulin G-binding protein Sbi, putative; Plays a role in the inhibition of both the innate and adaptive immune responses. Possesses two N-terminal domains that bind the Fc region of IgG and two domains that form a tripartite complex with complement factors C3b and CFH. By recruiting CFH and C3b, the secreted form acts as a potent complement inhibitor of the alternative pathway-mediated lysis; Belongs to the immunoglobulin-binding protein Sbi family. | Conserved hypothetical protein; Plays a role in the inhibition of host complement-mediated lysis and serum bactericidal activity by interacting with complement component C5. Affects all three pathways of complement activation and inhibits the cleavage of C5 by preventing its binding to C5 convertases. In turn, prevents C5a-mediated neutrophil migration. | 0.466 |
| scn | ABD30228.1 | SAOUHSC_02167 | SAOUHSC_01114 | Conserved hypothetical phage protein; Involved in countering the first line of host defense mechanisms. Efficiently inhibits opsonization, phagocytosis and killing of S.aureus by human neutrophils. Acts by binding and stabilizing human C3 convertases (C4b2a and C3bBb), leading to their inactivation. The convertases are no longer able to cleave complement C3, therefore preventing further C3b deposition on the bacterial surface and phagocytosis of the bacterium. Also prevents C5a-induced neutrophil responses; Belongs to the SCIN family. | Fibrinogen-binding protein. | 0.582 |
| scn | chp | SAOUHSC_02167 | SAOUHSC_02169 | Conserved hypothetical phage protein; Involved in countering the first line of host defense mechanisms. Efficiently inhibits opsonization, phagocytosis and killing of S.aureus by human neutrophils. Acts by binding and stabilizing human C3 convertases (C4b2a and C3bBb), leading to their inactivation. The convertases are no longer able to cleave complement C3, therefore preventing further C3b deposition on the bacterial surface and phagocytosis of the bacterium. Also prevents C5a-induced neutrophil responses; Belongs to the SCIN family. | Conserved hypothetical phage protein; Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leucyl-phenylalanine (fMLP). Acts by binding directly to the C5a receptor (C5aR) and formylated peptide receptor (FPR), thereby blocking the C5a- and fMLP-induced calcium responses (By similarity). Prevents phagocytosis of the bacterium; Belongs to the CHIPS/FLIPr family. | 0.618 |
| scn | flr | SAOUHSC_02167 | SAOUHSC_01112 | Conserved hypothetical phage protein; Involved in countering the first line of host defense mechanisms. Efficiently inhibits opsonization, phagocytosis and killing of S.aureus by human neutrophils. Acts by binding and stabilizing human C3 convertases (C4b2a and C3bBb), leading to their inactivation. The convertases are no longer able to cleave complement C3, therefore preventing further C3b deposition on the bacterial surface and phagocytosis of the bacterium. Also prevents C5a-induced neutrophil responses; Belongs to the SCIN family. | Conserved hypothetical protein; May be involved in countering the first line of host defense mechanisms. Impairs the leukocyte response to FPRL1 agonists by binding directly to host FPRL1 (By similarity); Belongs to the CHIPS/FLIPr family. | 0.498 |
