| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABD29650.1 | clpC | SAOUHSC_00501 | SAOUHSC_00505 | Conserved hypothetical protein. | Endopeptidase, putative; Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP. Required for biofilm formation. May act as a chaperone regulating CtsR activity. | 0.613 |
| ABD29650.1 | ctsR | SAOUHSC_00501 | SAOUHSC_00502 | Conserved hypothetical protein. | Conserved hypothetical protein; Negative regulator of clpC, clpB and clpP transcription by binding directly and specifically to their promoter region. | 0.612 |
| ABD29650.1 | mcsA | SAOUHSC_00501 | SAOUHSC_00503 | Conserved hypothetical protein. | UvrB/uvrC motif domain protein; Activates the phosphorylation activity of the protein- arginine kinase McsB (By similarity). May function as an important molecule for oxidative tolerance in various types of stress including that of heavy metals. Binds to Cu(2+), Zn(2+), Co(2+) and Cd(2+) via its CXXC metal binding motifs. | 0.619 |
| ABD29650.1 | mcsB | SAOUHSC_00501 | SAOUHSC_00504 | Conserved hypothetical protein. | ATP:guanido phosphotransferase, C-terminal catalytic domain protein; Catalyzes the specific phosphorylation of arginine residues in proteins (By similarity). Is required for stress tolerance and virulence in S.aureus. Acts as a modulator of the repressor activity of CtsR upon heavy metal and oxidative stress caused by these metal ions. | 0.619 |
| ABD29650.1 | pdp | SAOUHSC_00501 | SAOUHSC_02377 | Conserved hypothetical protein. | Pyrimidine nucleoside phosphorylase, putative; Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. | 0.502 |
| clpC | ABD29650.1 | SAOUHSC_00505 | SAOUHSC_00501 | Endopeptidase, putative; Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP. Required for biofilm formation. May act as a chaperone regulating CtsR activity. | Conserved hypothetical protein. | 0.613 |
| clpC | ctsR | SAOUHSC_00505 | SAOUHSC_00502 | Endopeptidase, putative; Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP. Required for biofilm formation. May act as a chaperone regulating CtsR activity. | Conserved hypothetical protein; Negative regulator of clpC, clpB and clpP transcription by binding directly and specifically to their promoter region. | 0.945 |
| clpC | mcsA | SAOUHSC_00505 | SAOUHSC_00503 | Endopeptidase, putative; Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP. Required for biofilm formation. May act as a chaperone regulating CtsR activity. | UvrB/uvrC motif domain protein; Activates the phosphorylation activity of the protein- arginine kinase McsB (By similarity). May function as an important molecule for oxidative tolerance in various types of stress including that of heavy metals. Binds to Cu(2+), Zn(2+), Co(2+) and Cd(2+) via its CXXC metal binding motifs. | 0.962 |
| clpC | mcsB | SAOUHSC_00505 | SAOUHSC_00504 | Endopeptidase, putative; Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP. Required for biofilm formation. May act as a chaperone regulating CtsR activity. | ATP:guanido phosphotransferase, C-terminal catalytic domain protein; Catalyzes the specific phosphorylation of arginine residues in proteins (By similarity). Is required for stress tolerance and virulence in S.aureus. Acts as a modulator of the repressor activity of CtsR upon heavy metal and oxidative stress caused by these metal ions. | 0.983 |
| ctsR | ABD29650.1 | SAOUHSC_00502 | SAOUHSC_00501 | Conserved hypothetical protein; Negative regulator of clpC, clpB and clpP transcription by binding directly and specifically to their promoter region. | Conserved hypothetical protein. | 0.612 |
| ctsR | clpC | SAOUHSC_00502 | SAOUHSC_00505 | Conserved hypothetical protein; Negative regulator of clpC, clpB and clpP transcription by binding directly and specifically to their promoter region. | Endopeptidase, putative; Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP. Required for biofilm formation. May act as a chaperone regulating CtsR activity. | 0.945 |
| ctsR | mcsA | SAOUHSC_00502 | SAOUHSC_00503 | Conserved hypothetical protein; Negative regulator of clpC, clpB and clpP transcription by binding directly and specifically to their promoter region. | UvrB/uvrC motif domain protein; Activates the phosphorylation activity of the protein- arginine kinase McsB (By similarity). May function as an important molecule for oxidative tolerance in various types of stress including that of heavy metals. Binds to Cu(2+), Zn(2+), Co(2+) and Cd(2+) via its CXXC metal binding motifs. | 0.996 |
| ctsR | mcsB | SAOUHSC_00502 | SAOUHSC_00504 | Conserved hypothetical protein; Negative regulator of clpC, clpB and clpP transcription by binding directly and specifically to their promoter region. | ATP:guanido phosphotransferase, C-terminal catalytic domain protein; Catalyzes the specific phosphorylation of arginine residues in proteins (By similarity). Is required for stress tolerance and virulence in S.aureus. Acts as a modulator of the repressor activity of CtsR upon heavy metal and oxidative stress caused by these metal ions. | 0.995 |
| mcsA | ABD29650.1 | SAOUHSC_00503 | SAOUHSC_00501 | UvrB/uvrC motif domain protein; Activates the phosphorylation activity of the protein- arginine kinase McsB (By similarity). May function as an important molecule for oxidative tolerance in various types of stress including that of heavy metals. Binds to Cu(2+), Zn(2+), Co(2+) and Cd(2+) via its CXXC metal binding motifs. | Conserved hypothetical protein. | 0.619 |
| mcsA | clpC | SAOUHSC_00503 | SAOUHSC_00505 | UvrB/uvrC motif domain protein; Activates the phosphorylation activity of the protein- arginine kinase McsB (By similarity). May function as an important molecule for oxidative tolerance in various types of stress including that of heavy metals. Binds to Cu(2+), Zn(2+), Co(2+) and Cd(2+) via its CXXC metal binding motifs. | Endopeptidase, putative; Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP. Required for biofilm formation. May act as a chaperone regulating CtsR activity. | 0.962 |
| mcsA | ctsR | SAOUHSC_00503 | SAOUHSC_00502 | UvrB/uvrC motif domain protein; Activates the phosphorylation activity of the protein- arginine kinase McsB (By similarity). May function as an important molecule for oxidative tolerance in various types of stress including that of heavy metals. Binds to Cu(2+), Zn(2+), Co(2+) and Cd(2+) via its CXXC metal binding motifs. | Conserved hypothetical protein; Negative regulator of clpC, clpB and clpP transcription by binding directly and specifically to their promoter region. | 0.996 |
| mcsA | mcsB | SAOUHSC_00503 | SAOUHSC_00504 | UvrB/uvrC motif domain protein; Activates the phosphorylation activity of the protein- arginine kinase McsB (By similarity). May function as an important molecule for oxidative tolerance in various types of stress including that of heavy metals. Binds to Cu(2+), Zn(2+), Co(2+) and Cd(2+) via its CXXC metal binding motifs. | ATP:guanido phosphotransferase, C-terminal catalytic domain protein; Catalyzes the specific phosphorylation of arginine residues in proteins (By similarity). Is required for stress tolerance and virulence in S.aureus. Acts as a modulator of the repressor activity of CtsR upon heavy metal and oxidative stress caused by these metal ions. | 0.999 |
| mcsB | ABD29650.1 | SAOUHSC_00504 | SAOUHSC_00501 | ATP:guanido phosphotransferase, C-terminal catalytic domain protein; Catalyzes the specific phosphorylation of arginine residues in proteins (By similarity). Is required for stress tolerance and virulence in S.aureus. Acts as a modulator of the repressor activity of CtsR upon heavy metal and oxidative stress caused by these metal ions. | Conserved hypothetical protein. | 0.619 |
| mcsB | clpC | SAOUHSC_00504 | SAOUHSC_00505 | ATP:guanido phosphotransferase, C-terminal catalytic domain protein; Catalyzes the specific phosphorylation of arginine residues in proteins (By similarity). Is required for stress tolerance and virulence in S.aureus. Acts as a modulator of the repressor activity of CtsR upon heavy metal and oxidative stress caused by these metal ions. | Endopeptidase, putative; Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP. Required for biofilm formation. May act as a chaperone regulating CtsR activity. | 0.983 |
| mcsB | ctsR | SAOUHSC_00504 | SAOUHSC_00502 | ATP:guanido phosphotransferase, C-terminal catalytic domain protein; Catalyzes the specific phosphorylation of arginine residues in proteins (By similarity). Is required for stress tolerance and virulence in S.aureus. Acts as a modulator of the repressor activity of CtsR upon heavy metal and oxidative stress caused by these metal ions. | Conserved hypothetical protein; Negative regulator of clpC, clpB and clpP transcription by binding directly and specifically to their promoter region. | 0.995 |
